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New Nile Blue derivatives as NIR fluorescent probes and antifungal agents
Published: 14 November 2018 by MDPI in The 22nd International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products Chemistry
Abstract: The development of new NIR fluorescent probes is a very important issue due to the wide range of applications. Benzo[a]phenoxazines are molecules with fluorescence at around 600 nm and have been reported also as antifungal agents. Herein, the synthesis of four new Nile Blue derivatives with hydrogen, propyl and/or aminopropyl groups as substituents of the amines of 5- and 9-positions is described. Photophysical properties are evaluated in acidified ethanol and aqueous solution at physiological pH. Antifungal activity is also evaluated through the obtention of MIC values.
Keywords: Benzo[a]phenoxazines, Nile Blue derivatives, NIR fluorescent probes, antifungal agents.