Synthesis new nucleoside of 1,3-bis-(2,3,5-tri-O-benzoyl-&beta;-D-ribofuranosyl)-8-(trifluoromethyl)-2-methyl-4-quinazolinone

Laila Break; Wafa Al-Harthi

doi:10.3390/ecsoc-22-05694

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Synthesis new nucleoside of 1,3-bis-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-8-(trifluoromethyl)-2-methyl-4-quinazolinone

Laila M Break

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Wafa Saad Al-Harthi

¹ Taif University
² Taif University, KSA

Published: 14 November 2018 by MDPI in The 22nd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-22-05694

Abstract:

Fluorinated nucleosides very important in increased biological and chemical stability of organ fluorine compounds. Synthesis of (1H)-8-trifluloromethyl-2-methyl-4-quinazolinone 3 from 2-amino-3-(trifluoromethyl) benzoic acid 1. Ribosylation of compound 4 with 1-O-acetyl-2,3,5-tri-O-benzoyl-

Keywords: 1-O-Acetyl-2,3,5-trihydroxy--D-ribofuranose, Nucleosides, 2-Methyl-4-quinazolinone, Trifluoromethylquinazolinone.

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