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Risk Assessment of Chemical Contaminants Ingestion with Nutrition of Children Aged 3–6 Years Old from the City of Kazan
* 1, 2 , 1, 2 , 1, 2 , 2, 3
1  Kazan Federal University, Institute of Fundamental Medicine and Biology, K. Marx str., 76, 420008, Kazan, Russia
2  KFU
3  1 Kazan Federal University, Institute of Fundamental Medicine and Biology, K. Marx str., 76, 420008, Kazan, Russia 2 FBUZ "Center of Hygiene and Epidemiology in the Republic of Tatarstan" (Tatarstan)

Abstract:

The analysis of the such chemicalsas cadmium (Cd), lead (Pb), arsenic (As), mercury (Hg) intake with the diet of children aged 3-6 years oldfrom the city of Kazan for periods (2007-2010 and 2011-2014) was carried out. The study of actual child nutrition was performed by questionnaire andtime-weight methods. The calculation of daily doses was made with the account of regional exposure factors at the 95thperc level. The non-carcinogenic risk from the exposure to methylmercury with basic food groupsat the level of the 95th perc made 3.89 and 3.33 for both periods, 10.67– for arsenic in the first period, being unacceptable (HQ >1). In 2007-2010, the central nervous system (CNS), the hormone system (HS), the immune system (IS), and the development (HI = 15.75, 12.87, 11.72 and 4.03) were exposed to the highest toxic effect. An in 2011-2014, the CNS and the development (HI = 4.02 and 3.98) were. The risk of developing non-carcinogeni ceffects for these systems (64% - 91 %) was mainly due to contamination of foods with As for the first period, and– to the intake of Pb (46 % - 57%) for the second period. The value of the total individual carcinogenic risk (ICRCd, Pb, As), for the second period (1.69Е-05) corresponds to maximum allowable level. In 2007-2010, the total ICRmade 2.45Е-04, which is an unacceptable level for the population. The major contribution to the total ICR due to the intake of contaminated foods was made by As –92.55 % in the first period, and by Cd – 79.93 % in the second period.

The peculiarities of the child body (the amount of chemicals ingested per kilogram of the body weight is higher in children than in adults), determine the potential risk and are responsible for high vulnerability on exposure to chemicals and development of adverse effects.

Keywords: chemical contaminants; foods; non-carcinogenic and carcinogenic risk assessment; the child population
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