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Solvent free synthesis of imidazo [1,2-a] pyridin- tetrazolo [1,5-a] quinolones via a IMCR one-pot process.
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1  Universidad de Guanajuato, División de Ciencias Naturales y Exactas, Departamento de Química


Solvent-catalyst free synthesis of poly-heterocycles containing imidazo[1,2-a]pyridine and Tetrazolo[1,5-a]quinoline frameworks via a one-pot process: IMCR Groebke-Blackburn-Bienaymé reaction (GBBR)/SNAr/ ring-chain azido tautomerization under ecofriendly conditions. The Tetrazolo[1,5-a]quinoline and imidazo [1,2-a] pyridine scaffolds are the structural core of various compounds with interesting pharmacological properties and could lead to the discovery of novel bioactive molecules.

Keywords: Isocyanide based multicomponent reactions; Groebke-Blackburn-Bienaymé reaction; Tetrazolo [1,5-a] quinolines; ring-chain azido tautomerization; one-pot process.