The work reports synthesis of ten novel derivatives of N-(2-substituted phenyl)- 4-oxothiazolidine-3-carbonothioyl benzamide derivatives 6(a-j) were synthesized by cyclization of key compounds N-(benzylidenecarbamothioyl)-benzamide using thioglycolic acid in solvent DMF and catalyst anhydrous ZnCl₂ using ultra-sonicator as an eco-friendly synthetic route. The nitrogen and sulphur containing heterocycle such as thiazolidinone has attracted continuing interest because of its varied biological activities. With the coupling of benzamide the anticancer activity of thiazolidinone derivatives is enhanced. Out of the 10 derivatives, 6a and 6c were found to have potential activity against MCF7 cell line whereas 6d and 6h exhibited potential activity against both the cell lines MCF7 and HeLa cell line. As the synthesized derivatives showed good anticancer activity this moiety can be further studied and modified to help in development of anticancer drug. The structures of the synthesized compounds were confirmed by spectral characterization such as IR, ¹H NMR, ¹³CNMR and Mass spectral studies.