An efficient synthesis of alkyne-3-tetrazolyl-Tetrazolo[1,5-a] quinolone via a one-pot process: I-MCR Ugi-azide /S_NAr/ ring-chain azido tautomerization under ecofriendly conditions. We report the one-pot synthesis of tris-heterocycles containing the tetrazolo[1,5-a]quinoline bound with 1,5-disubstituted-tetrazole (1,5-DS-T). The synthesis of this compounds can be of high interest for synthetic and medicinal chemistry because all the heterocycles are considered privilegied scaffolds and could lead to the discovery of novel bioactive molecules.