Structure-antimicrobial activity relationship of a series of functionalized arylbenzothiazoles

¹ Equipe de Chimie Moléculaire du Laboratoire CMGPCE, EA 7341, Conservatoire national des arts et métiers, 2 rue Conté,75003, HESAM Université, Paris France
² Laboratoire de Biotechnologie Microbienne et d’Ingénierie des Enzymes (LBMIE). Centre de Biotechnologie de Sfax, Université de Sfax, Route de Sidi Mansour Km 6, BP 1177, 3018 Sfax, Tunisie

Published: 13 January 2019 by MDPI in MOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed. congress CHEMBIOINFO-04: Chem-Bioinformatics Congress Cambridge, UK-Chapel Hill and Duluth, USA, 2018

https://doi.org/10.3390/mol2net-04-06133

Abstract:

The antibacterial activity of a series of functionalized arybenzothiazoles was investigated against Gram-positive pathogens including Staphylococcus aureus (ATCC 9144), Micrococcus luteus (LB14110), Salmonella enterica (NCTC 6017) and Gram-negative foodborne Pseudomonas aeruginosa (ATCC 9027), Escherichia coli (ATCC 8739). The antifungal activity was also evaluated against the opportunistic pathogenic yeast Candida albicans (ATCC 2091). The results displayed that these compounds exhibit a good antimicrobial activity compared with fusidic acid. The structure-antimicrobial activity relationships are also discussed

Keywords: arylbenzothiazoles; antibacterial activity; antifungal

View paper View Poster

154 Reads
0 Recommendations

Abdmlouleh Fatma

Mehdi El Arbi

Maité Sylla-Iyarreta Veitía

Mamdouh Ben Ali

Clotilde Ferroud