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Synthesis of polycyclic quinolines using SiO2/H2SO4 via Friedlӓnder synthetic method
* 1 , 1 , 1 , 1 , 2
1  Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 702843, Santiago de Chile, Chile.
2  Departamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Av. Angamos 601, Antofagasta, Chile.


An attention to the novel synthetic route for the polycyclic quinolines (3 & 5) from cyclic-diketones, cyclohexan-1,2-dione (2) / cyclohexan-1,3-dione (4) with o-aminoarylketones (1) in the presence of SiO2/H2SO4 yielded via Friedlӓnder synthetic method. The catalytic efficiency of the SiO2/H2SO4 was discussed through their utilization in the synthesis of biologically active substituted polycyclic quinoline derivatives (3 & 5) and the mechanism has been proposed. The SiO2/H2SO4 was found as a effective catalyst for the Friedlӓnder reaction and gave considerable isolated yield of the targeted products under the mild reaction condition. The synthesized polycyclic quinolines (3 & 5) were characterized through diverse analytical techniques like FT-IR, NMR spectroscopy and single crystal X-ray diffraction studies.

Keywords: Friedlӓnder synthetic method; polycyclic quinolines; SiO2/H2SO4