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Synthesis of 3-tetrazolylmethyl-4H-chromen-4-ones via Ugi-azide reaction catalyzed by ZnO nanoparticles
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1  Universidad de Guanajuato, División de Ciencias Naturales y Exactas, Departamento de Química


A serie of novel 3-tetrazolylmethyl-4H-chromen-4-ones were synthesized via Ugi-azide reaction under mild ultrasound-assisted conditions (room temperature, EtOH, 10% mol ZnO nanoparticles). The products containing two privileged heterocyclic frameworks: 1,5- disubstituted-1H-tetrazole and 3-substituted-4H-chromen chromen-4-ones, which are present in a variety of bioactive compounds and commercial drugs.

Keywords: Ugi-azide; chromone; ultrasound-assisted; ZnO nanoparticles