2D Polar Co-ordinate Representation of Amino Acid Sequences With some applications to Ebola virus, SARS and SARS-CoV-2 (COVID-19)

Tathagata Dey; Subhamoy Biswas; Shreyans Chatterjee; Smarajit Manna; Ashesh Nandy; Subhas Basak

doi:10.3390/mol2net-06-06790

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2D Polar Co-ordinate Representation of Amino Acid Sequences With some applications to Ebola virus, SARS and SARS-CoV-2 (COVID-19)

Tathagata Dey

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1, 2},

Subhamoy Biswas

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2, 3},

Shreyans Chatterjee

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2, 4},

Smarajit Manna

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2, 5},

Ashesh Nandy

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2},

Subhas C Basak

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2, 6}

¹ Computer Science Department, Government College of Engineering and Textile Technology, Serampore-712201, India
² Centre for Interdisciplinary Research and Education, Kolkata-700068, India
³ Electrical Engineering Department, Jadavpur University, Kolkata-700032, India
⁴ Microbiology Department, St. Xavier’s College, Kolkata-700016, India
⁵ Jagadis Bose National Science Talent Search, Kolkata 700107, India
⁶ Department of Chemistry and Biochemistry, University of Minnesota, Duluth, MN, USA; sbasak@d.umn.edu

Published: 11 April 2020 by MDPI in MOL2NET'20, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 6th ed. congress USINEWS-04: US-IN-EU Worldwide Science Workshop Series, Duluth, USA, 2020

https://doi.org/10.3390/mol2net-06-06790

Abstract:

We consider a novel approach to mathematically define a graphing method to represent amino acid sequences of proteins in two-dimensional plane and characterize them numerically. The amino acids are represented by their relative magnitude of their hydrophobicity. Each amino acid is compared with a vector and moves in relative direction which generates a graph. Applications are shown in Zaire Ebola Virus to conclude how this plotting can be more useful than base sequence plotting. Also, superimposition graph of SARS and SARS-CoV-2 shows that these sequences are strongly related and Various other applications are shown too to explain it's fruitfulness.

Keywords: Protein Graph;Graphical Representation;Numerical Characterization;Polar Coordinate;Polar Plot;Amino Acid

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Comments on this paper

Guillermin Agüero-Chapin

5 January 2021

Graphical Representation of Proteins

Hi Dear Authors

Do believe that graphical representation of proteins could be generalized in a near future for comparative sequence analysis as traditional alignments do? or to improve them? Thanks in advance

Shreyans Chatterjee