Inflammatory processes, although important for tissue homeostasis, can suffer imbalances and be related to several diseases. An important enzyme involved in the mediation of inflammatory processes is cyclooxygenase 2 (COX-2), which generates prostaglandins from arachidonic acid. In this context, this enzyme is an important drug target and its inhibition is a mechanism present in several anti-inflammatory drugs. The chlorogenic acid (CHLORO) could act in an inhibitory way on COX-2 and there are reports of anti-inflammatory actions of this molecule. To evaluate the possible inhibitory power on COX-2 of chlorogenic acid through molecular docking was the objective of this study. The docking simulation by AutoDock Vina demonstrated a binding energy with the COX-2 of -9.5 Kcal/mol. Besides that, COX-2 and CHLORO stablished 09 Hydrogen bonds and 06 hydrophobic interactions. The binding energy and types of binding established with COX-2 can demonstrate the anti-inflammatory properties of the CHLORO. In this sense, it would be important to continue in vitro and in vivo studies.