Prevention of the probe hole clogging up during administration of nano Ag preparations in animal models of gastrointestinal diseases

¹ Department of Vehicles and Fundamentals of Machine Design, Lodz University of Technology, Poland, Stefanowskiego Str. 1/15, 90-537 Lodz, Poland
² Institute of Vehicles and Construction Machinery Engineering, Warsaw University of Technology, Poland, Narbutta Str. 84, 02-524 Warsaw, Poland
³ Department of Bioinorganic Chemistry, Chair of Medicinal Chemistry, Medical University of Lodz, Muszynskiego Str. 1, 90-151 Lodz, Poland

Published: 06 November 2020 by MDPI in 6th International Electronic Conference on Medicinal Chemistry session General: Presentations

https://doi.org/10.3390/ECMC2020-07463

Abstract:

The present study concerns the resistance to motion of syringe plunger against syringe barrel during intragastrical administration of silver preparations into mice models of gastrointestinal diseases. The mathematical model of drug flow in the syringe barrel-hub-needle assembly was elaborated and presented. The effect of geometrical parameters of the mentioned assembly affecting the resistance to motion was profoundly investigated. The resistance to motion during administration of silver preparation depended mainly on the needle hole diameters and hub hole. The form of silver preparation and length of needle only slightly affected the resistance to motion. The important role of albumin in prevention of Ag nanoparticles agglomeration was found.

Keywords: Ag preparations, animal model, anti-clogging, gastrointestinal tract

View Poster Download (presentation ppt)

68 Reads
0 Recommendations

Krzysztof Siczek

Przemyslaw Kubiak

Justyn Ochocki