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Synthesis and Antimicrobial Activity of Novel Heterocyclic Chalcones
Published: 31 October 2011 by MDPI in The 15th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products
Abstract: In a wide search program toward new antimicrobial agents, a seri of heterocyclic chalcones have been synthesized by condensing benzaldehyde derivatives with heteroarylmethylcetone in potassium hydroxide methanol according to the Claisen-Schmidt condensation at room temperature. The synthetic chalcones have been determined by IR spectroscopy and 1H-NMR spectroscopy. The antimicro-bacterial activity of the novel products was evaluated against bacteria such as Staphylococcus aureus, Pseudomonas aeruginosae, E. coli and fungi such as Candida albicans, dermatophytes. The result shows that pyridine moiety may show antibacterial effect stronger than that of thiophene or furan. Heterocyclic chalcones with hydroxyl group on B ring at position 2 or 3 are considered as lead compounds for generation of new potential antimicrobial drugs in future.
Keywords: Heterocyclic chalcone derivates, Antimicrobial agents