Synthesis of new 2-oxonicotinic acids

Published: 14 November 2020 by MDPI in The 24th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-24-08365

Abstract:

2,2-Dimethyl-5-((phenylamino)methylene)-1,3-dioxane-4,6-dione, prepared by ternary condensation of Meldrum’s acid with triethyl orthoformate and aniline, reacts with N-aryl cyanoacetamides in the presence of KOH to give 2-oxo-1,2-dihydropyridine-3-carboxylic acids, which are useful as drug precursors or perspective ligands.

Keywords: nicotinic acids; Meldrum’s acid; 2-oxo-1,2-dihydropyridine-3-carboxylic acid; cyanoacetamides

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