The aim of this study was to assess the potential of the Moroccan Rif (northern Morocco) with regard to medicinal and aromatic plants used in the treatment of genito-urinary diseases. The ethnobotanical survey was conducted in Moroccan Rif region for two campaigns from 2016 to 2018. I n total, 548 local traditional healers were interviewed. Information was collected using open-ended and semi-structured interviews, analyzed and compared by quantitative ethnobotanical indices such as family importance value (FIV), relative frequency of citation (RFC), plant part value (PPV), fidelity level (FL) and informant consensus factor (ICF) were used to analyze the obtained data. The study identified a total of 27 medicinal and aromatic plant species belonging to 18 botanical families. The most important family is that of the Rutaceae represented by 04 species. Concerning the diseases treated, kidney stones diseases have the highest ICF (0.97), the leaf was considered the most used part of the plant (PPV=0.443) and the majority of the remedies were prepared in the form of decoction. The results of the present study showed the existence of indigenous ethnomedicinal knowledge of medicinal and aromatic plants in the Moroccan Rif to treat genito-urinary diseases. Further research on phytochemical, pharmacological and other biological activities should be considered to discover new drugs from these documented plants.