Age-related macular degeneration (AMD) is a disease that causes progressive loss of sharp central vision. AMD is characterized by the presence of extracellular debris called drusen. In this contribution, the effect of drusen size on the morphological changes in the layers of the outer retina i.e. RPE, BrM and photoreceptors is investigated using the cellular potts model (CPM) and methods of machine learning. Numerical simulation of the influence of drusen growth and its effect on the morphology of the outer retinal layers of the macula is presented.