Marine litter, that is solid materials deliberately or accidentally released into marine and coastal environments, is a growing issue both at local and global scale. In particular, litter accumulation on beaches represents a relevant problem in touristic coastal areas. The DPSIR framework, already applied to tackle other environmental issues, can help in analysing the origin, impact, and possible solution of material stranded on the beach allowing a holistic approach in the “one health” perspective. It was applied in a popular sandy bathing location in the North-Western Tuscany (Italy). Information and data on origin and fate of beach-stranded material as well as existing local strategies were retrieved from a stakeholders’ network. In summer 2020, a monitoring campaign was performed to evaluate the sanitary state of the shoreline and the impact of this material on coastal habitat. In a 7-year period (2014-2020), a mean amount of 1.548,3 tons of beach-stranded material have been collected and treated to separate sand (55%), organic green fraction (31%), and anthropogenic debris (2%), while 12% weight-loss was attributable to evaporation. Analysis of historical environmental data revealed that shoreline accumulation of this material was associated with low atmospheric pressure, medium-strong winds, and storms. Preliminary monitoring data showed that the green fraction was mainly represented by wood and terrestrial plants with little quantity of the seagrass Posidonia oceanica, while most of the anthropogenic debris was rubber and metal. Microbial pollution of beached material was at least one order of magnitude higher than the surrounding environment (sand and seawater) for total coliforms, Escherichia coli, intestinal enterococci, and total fungal load. Overall, our results indicate a potential impact of beach-stranded material in this coastal area, with possible health risk for human population. The instruments already in place for the management of beached material, although consistent, could be further improved.