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Site Selective Monoacylation of Pyrroles through Palladium-Catalyzed C-H Activation with Aldehydes. Synthesis of Pyrrolomycins
Published:
15 January 2021
by MDPI
in MOL2NET'20, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 6th ed.
congress CHEMBIOMOL-06: Chem. Biol. & Med. Chem. Workshop, Bilbao-Rostock, Germany-Galveston, Texas, USA, 2020
https://doi.org/10.3390/mol2net-06-09175
(registering DOI)
Abstract:
Site selective monoacylation of pyrroles has been achieved via Pd(II)-catalyzed C-H activiation with aldehydes in the presence of TBHP as oxidant using the 3-methyl-2-pyridine as directing group. The reaction has been extended to different aromatic and heteroaromatic aldehydes for the synthesis of a series of di(hetero)aryl ketones. The utility of the methodloogy has been demonstrated in the synthesis of pyrrolomycins, as Celastramycin analogues and Tolmetin.
Keywords: Organic chemistry; Palladium; Pyrrolomicyns; Pyrroles
