Hydrogels can display a wide variety of chemical and physical properties that enable them as nanostructured scaffolds for tissue engineering. Yet, single-component hydrogels have inherent limitations. To enhance and reinforce the versatility of the single component, different multi-component hydrogels have been designed and characterized. The influence of the nanoscascale of the systems on their macroscopic response was assessed, demonstrating that with a proper composition, multifunctional hybrid hydrogels can be optimally designed and successfully developed.