Bioceramic nanoparticles have a variety of characteristics that make them an ideal material for hard tissue engineering. However, knowing their success within the fluids of the human body is vital to fully comprehend their behaviour. The interaction of hydroxyapatite nanorods (HA) and bovine serum albumin (BSA) was investigated in order to accomplish this task. Using a variety of techniques, the key features of the physiological interaction between BSA and hydroxyapatite nanoparticle are discussed. Experimental data were collected using specific approaches to determine critical parameters including rates, affinities, and stoichiometries.