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Semi-Synthesis and Anti-Herpetic Activity of New Riolozatrione Derivatives
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Published:
01 November 2016
by MDPI
in The 20th International Electronic Conference on Synthetic Organic Chemistry
session Bioorganic, Medicinal and Natural Products Chemistry
Abstract:
Riolozatrione is a natural diterpene isolated form Jatropha dioica to which anti-viral activity is attributed. In this work we report the synthesis of 5 new derivatives and its anti-herpetic evaluation. Riolozatrione posses a unique diterpene core attractive for chemical modification. Conjugate ketone was selectively hydrogenated whereas sodium borohydride draws for three different riolozatrione analogues.
