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Antimicrobial Electrospun Cellulose Acetate Micro-fibers Loaded with Oregano and Rosemary Essential Oil
Ioannis Liakos * 1 , Alina Maria Holban 2 , Riccardo Carzino 1 , Simone Lauciello 1 , Alexandru Mihai Grumezescu 3
1  Istituto Italiano di Tecnologia
2  Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Aleea Portocalelor, No. 1-3, Bucharest 060101, Romania
3  Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1-7, Bucharest 011061, Romania

Published: 04 November 2016 by MDPI AG in 2nd International Electronic Conference on Medicinal Chemistry session ECMC-2
10.3390/ecmc-2-A033
Abstract:

The method of electrospinning was used to create micro-fibers made of cellulose acetate (CA) and essential oils (EOs). CA polymer at 15% w/v was dissolved in acetone and then 1 or 5% v/v of EOs were added to the polymer solution. The essential oils chosen were oregano and rosemary oils. Then the CA-EOs in acetone solution was electrospun creating fibers with approximately 1.0 – 2.0 μm in diameter. Scanning electron microscopy was used to study the morphology, topography and dimensions of the micro-fibers. Raman spectroscopy was used to detect attachment of the EOs in the CA electrospun micro-fibers. The formed CA-EOs micro-fibers found to have good antimicrobial properties against three common bacteria strains; S. aureus, E. coli and C. albicans. The more concentrated with EOs micro-fibers showed the best antimicrobial effects. This work describes an effective and simple method to prepare CA-EOs micro-fibers and open new ways for many applications of such electrospun fibers such as wound dressings, anti-biofilm surfaces, sensors, packaging, cosmetics etc.

Keywords: Antimicrobial; antibacterial; essential oils; anti-biofilm; wound dressings; cellulose acetate; electrospun fibers.
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