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Design and Characterization of Polymeric Floating Microspheres of Levofloxacin Hemihydrate.
Vaibhav V Kulkarni * 1 , Sagar Arekar 1 , Lalit V Sonawane 2
1  School of Pharmacy, Swami Ramanand Tirth Marathwada University, Nanded 431306, India
2  Department of Quality Assurance , Maharashatra College of Pharmacy, Nilanga.


The complex of Levofloxacin and Chitosan lead to formation of water soluble complex. This complex of Levofloxacin was then formulated into floating beads calcium alginate  with maximum entrapment of Levofloxacin found to be about 75 %( f10) and the entrapment was found to be significantly higher as compared to the other formulations ( f1 to f9). In- Vitro Release studies of the beads f10 was found to significantly improve the release of Levofloxacin as compared to other formulations.. The mean particle size of f10 microspheres and surface morphology were determined by SEM Resulting in Porous and Rough Surface of microspheres.The drug release kinetics were studied as zero order, first order , Higuchi , Koresmeyer-Peppas equations , good  linearity was found in Higuchi’s Equation (R2= 0.9310) indicating the release of the drug from Microspheres is  based on Fickian Diffusion .

Keywords: Levofloxacin, Chitosan, Calcium Alginate, Microsphers , release kinetics, SEM, Fickian Diffusion