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Cells Webinar | Nervous System Development and Plasticity in Model Organisms V

12 Jul 2021, 15:00

Cells, Disease, Nervous System, Plasticity, Model Organisms
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Welcome from the Chair

10th Webinar on Cells

Nervous System Development and Plasticity in Model Organisms V

The Nervous system is essential for receiving, transferring, and processing information, which allows us to make important decisions and carry out everyday tasks. It is composed of two main cell populations, which are the neurons and the glial cells.
As the central part of the nervous system, neurons process incoming information and transmit it to different parts of the body. Glial cells provide support and protection for neurons and are necessary for neural development, synapse and myelin formation and proper function of neurons. They also maintain the homeostasis of the nervous system as some population of glial cells can behave as neural stem cells during embryonic development and in adult stages.
During the development of an organism, the nervous system undergoes significant changes not only regarding its structure but also its function. Neurons, glial cells and the numerous molecular signals and components that are part of the nervous system, can play various roles during different stages of development and in different parts of the nervous system.
This webinar features several eminent experts in the field of nervous system development, maintenance and regeneration in different model organisms.

Date: 12 July 2021

Time: 3:00 pm CEST | 9:00am EDT | 9:00pm CST Asia

Webinar ID: 844 1340 6141

Webinar Secretariat:


Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany

Dr. Sepand Rastegar studied Biology at the University of Strasbourg, France, where he obtained his diploma degree in 1996. Dr. Sepand Rastegar completed his PhD in the laboratory of Prof. Walter Knöchel at the University of Ulm, Germany. In 2000, Dr. Sepand Rastegar moved back to Strasbourg to do 2 years of post-doctoral research with Prof. Uwe Strähle at the IGBMC. In 2002, Dr. Sepand Rastegar obtained a permanent position at the French National Institute of Health and Medical Research (INSERM). In 2005, Dr. Sepand Rastegar moved to Germany to work at the Karlsruhe Institute of Technology (KIT). Currently, Dr. Sepand Rastegar is investigating the molecular mechanisms that regulate zebrafish neurogenesis and regeneration. His models are the embryonic spinal cord and the adult telencephalon. His full list of publications is available at

Invited Speakers

Institute of Cell Biology and Anatomy, Biomedical Center of LMU, Munich, Germany

Jovica studied Molecular Biology and Physiology at University Belgrade. After his master thesis at the Institute of Molecular Genetics and Genetic Engineering in Belgrade, Jovica decided to move to Munich to join the team of Dr. Laure Bally-Cuif, where he investigated the molecular mechanisms of neurogenesis in zebrafish embryo. After a very successful PhD defence, he started a postdoc with Prof. Magdalena Götz to investigate the Neurogenesis and Regeneration in adult mouse and zebrafish models. Currently, Jovica works as a W2 Anatomy Professor at the Institute of Cell Biology and Anatomy, Biomedical Center of LMU, Munich. Jovica and his colleagues set up tools to follow fate commitment in the adult vertebrate brain using multi-colour clonal analysis in mouse (Calzolari et al., 2015; Bast et al., 2018) and live in vivo imaging in zebrafish (Barbosa et al., 2015; Barbosa et al., 2016). They were the first to address the behaviour of adult neural stem cells at the single cell level, including the implications in the neuronal repair.

Max Planck Institute for the Science of Light and the Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany

Daniel Wehner’s research interest is to unravel the mechanisms underlying successful organ regeneration in vertebrates. His goal is to inform research in non-regenerating systems. Daniel Wehner studied Bio- and Nanotechnologies at the South Westphalia University of Applied Sciences (Iserlohn, Germany). In parallel, he completed an intercalated BSc Honours degree in Medical Biotechnology at the Abertay Dundee (Dundee, United Kingdom). Following his undergraduate studies, Daniel Wehner carried out doctoral research in the laboratory of Prof. Gilbert Weidinger at the Technische University Dresden and Ulm University (Dresden / Ulm, Germany), where he studied mechanisms of tissue regeneration using the zebrafish fin as a model system. After completing his doctorate, Daniel Wehner conducted postdoctoral research in the laboratories of Prof. Catherina G. Becker at the University of Edinburgh (Edinburgh, United Kingdom) and Prof. Michael Brand at the Technische Universität Dresden (Dresden, Germany), focussing on mechanisms of successful spinal cord regeneration in zebrafish. Since November 2018, Daniel Wehner has been leading the junior research group ‘Neuroregeneration’ at the Max Planck Institute for the Science of Light and the Max-Planck-Zentrum für Physik und Medizin (Erlangen, Germany). His current research focusses on elucidating the principles that can lead to functional axonal regeneration in a complex vertebrate central nervous system, with emphasis on the regeneration-permissive microenvironment. For a list of publications, please see

Webinar Content

The tenth webinar of the MDPI journal Cells, entitled “Nervous System Development and Plasticity in Model Organisms V”, was held on Monday 12 July 2021. This online seminar was chaired by Dr. Sepand Rastegar (Karlsruhe Institute of Technology, Germany). Prof. Dr. Jovica Ninkovic and Dr. Daniel Wehner presented their research related to central nervous system regeneration.

The first speaker to kick off the webinar was Prof. Dr. Jovica Ninkovic and his presentation showed how the analysis of gliosis in different model organisms can unravel vertebrate brain regeneration. The second speaker was Dr. Daniel Wehner, and he presented his research on axon regeneration in the zebrafish spinal cord. Both presentations were followed by a Q&A session, moderated by the chair, to answer the questions submitted by live online attendees.

The webinar was offered via Zoom, and registration was required for attendance. The full recording can be found below.

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Time in CEST

Dr. Sepand Rastegar

Chair Introduction

3:00 - 3:05 pm

Prof. Dr. Jovica Ninkovic

Regeneration in Vertebrate Brain-Lessons From Analysis of Comparative Gliosis

3:05 - 3:50 pm

Dr. Daniel Wehner

A Switch in Pdgfrb+ Cell-Derived ECM Composition Prevents Inhibitory Scarring and Promotes Axon Regeneration in the Zebrafish Spinal Cord

3:50 - 4:35 pm

Q&A Session

4:35 - 4:55 pm

Closing of Webinar
Dr. Sepand Rastegar

4:55 - 5:00 pm

Relevant SI

Neurogenesis and Regeneration in the Zebrafish Central Nervous System
Guest Editor: Dr. Sepand Rastegar
Guest Editor: Ms. Luisa Lübke
Deadline for manuscript submissions: 28 February 2022

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