The 2nd International Electronic Conference on Genes
Part of the International Electronic Conference on Genes series
11–13 Dec 2024
human genomics, medical genetics, functional genomics, precision medicine, complex disorders, disease gene discovery
- Go to the Sessions
- Event Details
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- Welcome from the Chair
- Program Overview
- IECGE 2024 Program (DAY 1)
- IECGE 2024 Program (DAY 2)
- IECGE 2024 Program (DAY 3)
- Abstract Book
- Poster Gallery
- Event Chairs
- Event Speakers
- Sessions
- Registration
- Instructions for Authors
- Publication Opportunity
- List of Accepted Submissions
- Event Awards
- Sponsors and Partners
- Conference Secretariat
- Events in series IECGE
IECGE 2024 conference closed
The Best Oral Presentation Awards and Best Poster Awards of IECGE 2024 will be announced soon!
Click HERE for more details.
Welcome from the Chair
It is with great enthusiasm that we announce the 2nd International Electronic Conference on Genes (IECGE2024). The conference is organized by the MDPI open access journal Genes (ISSN: 2073-4425; Impact Factor: 2.8) and will be held online from 11th to 13th December 2024.
This conference will provide leading scientists with an online platform to share their latest research and engage in exciting discussions. The main topics and sessions of the conference are:
- Non-coding RNAs in Health and Diseases;
- Genetic Diagnosis and Targeted Therapy in Cancer;
- Microbial Genetics and Genomics;
- Technologies and Resources for Genetics Research ;
- Human Genomics and Genetic Diseases.
In the virtual conference, there are additional advantages: (1) engagement tools that keep energy levels high, (2) participants are given a voice, (3) far stronger attention is received while one is talking, (4) a Q&A through the Chat is also possible if you do not wish to raise your question verbally, (5) polls, (6) feedback through the Chat, (7) the use of “Reaction” functions to show your voice, appreciation, or a request, (8) greater reach with remote audiences, and (9) the ability to deliver live and pre-recorded presentations simultaneously.
All the accepted abstracts will be available online on Sciforum.net during and after the conference.
Kind regards,
Follow the conference organizer on Social Media
Program Overview
11th Morning | 12th Morning | 13th Morning |
Session 2. Genetic Diagnosis and Targeted Therapy in Cancer |
Session 5. Microbial Genetics and Genomics | Session 3. Human Genomics and Genetic Diseases |
11th Afternoon | 12th Afternoon | 13th Afternoon |
Session 1. Non-coding RNAs in Health and Diseases |
Session 4. Technologies and Resources for Genetics Research |
IECGE 2024 Program (DAY 1)
IECGE 2024 Day 1
Session B. Genetic Diagnosis and Targeted Therapy in Cancer
Date: 11th December 2024 (Wednesday)
Time: 9:00 (CET, Basel) | 03:00 (EDT, New York) | 16:00 (CST Asia, Beijing)
Time in CET |
Speaker |
Title |
09:00-09:10 |
Prof. Dr. Selvarangan Ponnazhagan |
Opening Speech |
09:10-09:20 |
Dr. Christos K. Kontos |
Welcome from the session chair |
09:20-09:50 |
Prof. Dr. Rana Ahmed Youness |
Liquid Biopsy-Guided Precision Immunotherapy: A special focus on LncRNAs in Young Breast Cancer Patients |
09:50-10:10 |
Dr. Leili Rejali |
Consensus molecular subgroups (CMS) in colorectal cancer management |
10:10-10:30 |
Dr. Katerina Katsaraki |
The Combination of Sequencing Approaches Unravels the Post-transcriptional Regulatory Effect of Proteasome Inhibitors, in Breast Cancer |
10:30-10:45 |
Amali Thannkoon |
The role of Iroquois-class homeobox genes in cancer stemness |
10:45-11:00 |
Saima Firdaus |
mRNA-Based Biomarker Identification for Targeted Therapy Development in Pancreatic Cancer |
11:00-14:00 |
BREAK |
Session A. Non-coding RNAs in Health and Diseases
Date: 11th December 2024 (Wednesday)
Time: 14:00 (CET, Basel) | 08:00 (EDT, New York) | 21:00 (CST Asia, Beijing)
Time in CET |
Speaker |
Title |
14:00-14:10 |
Prof. Dr. Laurent Metzinger |
Welcome from the Session Chair |
14:10-14:40 |
Prof. Dr. Laurent Metzinger |
Nobel price attributed to microRNAs timeline of the discovery and summarize the inaugural papers of Ambros and Ruvkun |
14:40-14:55 |
Emma Brisot |
Uremic toxins levels are associated with miR-223 in Chronic Kidney Disease-associated anemia |
14:55-15:10 |
Muhammad Safdar |
Decoding miRNA Interactions and SNP Variability in the 3'UTR of NF-κB: Implications for Gene Regulation and Cancer |
15:10-15:25 |
Irina Valerievna Pronina |
Association of the expression level of lncRNAs GAS5, HAND2-AS1, LINC00152, and LINC00339 and tumor size and the lymphogenous metastasis in clear cell renal cell carcinoma |
15:25-15:40 |
Mateusz Gotowiec |
miRNA dysregulation in the autophagy response induced by starvation in rat mammary epithelial cells and breast cancer cells |
IECGE 2024 Program (DAY 2)
IECGE 2024 Day 2
Session E. Microbial Genetics and Genomics
Date: 12th December 2024 (Thursday)
Time: 9:00 (CET, Basel) | 03:00 (EDT, New York) | 16:00 (CST Asia, Beijing)
Time in CET |
Speaker |
Title |
09:00-09:10 |
Dr. Silvia Turroni |
Welcome from the session chair |
09:10-09:40 |
Dr. Federica D'Amico |
Gut microbiome in infancy and childhood: a multiomic approach in health and disease |
09:40-10:10 |
Prof. Dr. Jianping Xu |
Population genomic analyses reveal diverse patterns of evolution in human fungal pathogens |
10:10-10:30 |
Dr. Mariachiara Mengoli |
Human Microbiome and Infections: (Not) Just the Two of Us |
10:30-10:45 |
Savanah Senn Selected Oral Speaker |
Artemisia californica draft leaf and flower transcriptome and soil WGS resources |
10:45-11:00 |
Niraj Kumar Prajapati Selected Oral Speaker |
Genomic basis of mycorrhizal fungal specificity in plant-fungal symbioses |
11:00-11:15 |
Alexey V. Rakov Selected Oral Speaker |
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11:15-11:30 |
Marcos Jessé Abrahão Silva |
Functional and Structural Characterization of Exonic SNPs associated with Leprosy Risk: an In Silico Analysis |
IECGE 2024 Program (DAY 3)
IECGE 2024 Day 3
Session C. Human Genomics and Genetic Diseases
Date: 13th December 2024 (Friday)
Time: 9:00 (CET, Basel) | 03:00 (EDT, New York) | 16:00 (CST Asia, Beijing)
Time in CET |
Speaker |
Title |
09:00-09:10 |
Prof. Dr. Dror Sharon |
Welcome from the session chair |
09:10-09:40 |
Prof. Carlo Rivolta |
An integrated bioinformatic toolbox for the analysis of rare disease genetic data |
09:40-10:10 |
Prof. Batsheva Kerem |
From gene cloning to mutation specific therapies in cystic fibrosis |
10:10-10:25 |
Manar Salameh |
A Founder Homozygous Nonsense Variant in CREB3 Causes a Variable Retinal Degeneration Phenotype |
10:25-10:40 |
Maria-Anna Kyrgiafini |
|
10:40-10:55 |
Husna Irfan Thalib |
|
10:55-11:10 |
Farhan Ikhtiar |
|
11:10-14:00 |
BREAK |
Session D. Technologies and Resources for Genetics Research
Date: 13th December 2024 (Friday)
Time: 14:00 (CET, Basel) | 08:00 (EDT, New York) | 21:00 (CST Asia, Beijing)
Time in CET |
Speaker |
Title |
14:00-14:10 |
Prof. Dr. Maria Luisa Chiusano |
Welcome from the Session Chair |
14:10-14:40 |
Dr. Yuval Itan |
Novel Machine Learning Approaches for Predicting Functional Consequences of Human Genetic Variants |
14:40-14:55 |
Savanah Senn |
A draft transcriptome of the climate resilient California native plant Ribes malvaceum |
14:55-15:10 |
Sakeena Bairamova |
An approach to identify aggression profiles via machine learning |
15:10-15:25 |
Tanya Ahmed Sheik |
|
15:25-15:40 |
Guillaume Pavlovic |
|
15:40-15:55 |
Raju Mondal |
Abstract Book
Event Chair
Department of Pathology, The University of Alabama at Birmingham, USA
Dr. Ponnazhagan is a trained molecular geneticist with a focus on cancer. He is currently a Full Professor and holds an Endowed Professorship in Experimental Cancer Therapeutics. The major research areas of Dr. Ponnazhagan’s lab are experimental cancer therapeutics, including stem cell and gene therapy using adeno-associated virus (AAV), tumor microenvironment (TME), and cancer bone metastasis. In reference to cancer-bone interaction, Dr. Ponnazhagan’s lab models breast cancer to adopt strategies that target tumor cells, immune suppression, and aggressive osteoclast functions. To overcome limitations in current therapies, his lab developed novel molecular tools and targeted delivery mechanisms, utilizing mesenchymal stem cells as effective therapeutic vehicles for bone remodeling in breast cancer osteolytic pathology. Towards targeting receptor activator of nuclear factor kappa-B ligand (RANKL) activation using osteoprotegerin (OPG), a decoy receptor for RANKL, without interfering in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of tumor cells, his lab developed an OPG mutant by structural protein engineering that lacks TRAIL binding affinity and validated in vivo in a disseminated osteolytic malignancy model. His group is the first one to identify a subset of immature myeloid cells, known as myeloid-derived suppressor cells, in the TME within the bone, directly undergo osteoclast differentiation and serve as osteoclast progenitors to enhance bone damage. Recent studies from his lab established the role of RANKL in activating M2 macrophages in breast cancer microenvironment and that dampening the effects of elevated RANKL using the OPG mutant resulted in a shift in the immune milieu favoring an anti-tumor cytokines and chemokine response.
Session Chairs
Prof. Dr. Laurent Metzinger
UPJV HEMATIM UR 4666, C.U.R.S, Université de Picardie Jules Verne, France
Dr. Christos K. Kontos
Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15701 Athens, Greece
Prof. Dr. Dror Sharon
Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel
Prof. Dr. Maria Luisa Chiusano
1. Department of Agriculture, University of Naples Federico II, Portici, 80055 Naples, Italy; 2. Department of Research Infrastructures for Marine Biological Resources, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
Dr. Silvia Turroni
Department of Pharmacy and Biotechnology, University of Bologna, Italy
Event Committee
Department of Cancer Biology and Genetics, Comprehensive. Cancer Center, The Ohio State University, Columbus, OH, USA.
Dr. Giovanni Nigita is a Principal Investigator in the Department of Cancer Biology and Genetics at The Ohio State University. His research focuses on multi-omics data analysis in cancer, with particular emphasis on non-coding RNAs, RNA modifications, and human endogenous retroviruses as gene regulatory systems. He is committed to advancing non-invasive cancer biomarker discovery and developing bioinformatics tools to enhance RNA biology research. Dr. Nigita integrates computational and experimental approaches to unravel complex regulatory networks in cancer, strongly emphasizing translating discoveries into practical applications. His efforts include the development of innovative bioinformatics platforms that are freely accessible to the scientific community. Dr. Nigita actively collaborates with researchers worldwide, aiming to advance the understanding and treatment of cancer through cutting-edge RNA-centric technologies. He is the author of more than 60 articles in international peer-reviewed journals and was awarded the Genes 2023 Young Investigator Award.
Computational Biology; Cancer informatics; ncRNA; RNA; modification; ncRNA Editing
Huffington Center on Aging & Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Hongjie got his bachelor’s degree from University of Science and Technology of China (USTC) in 2010, did his PhD with Dr. Henri Jasper at University of Rochester, New York, and then at Buck Institute for Research on Aging, California (2010-2016), and got his postdoctoral training with Dr. Liqun Luo at Stanford University (2016-2020). Hongjie started his own lab in early 2021 at Baylor College of Medicine (BCM). Currently, he is an assistant professor and CPRIT Scholar at Huffington Center on Aging & Department of Molecular and Human Genetics. He developed several single-cell/nucleus sequencing platforms in Drosophila (2017 Cell; 2020 Current Biology; 2021a eLife; 2021b eLife), and has been leading the Fly Cell Atlas project (2022 Science). His lab recently established the Aging Fly Cell Atlas for studying whole organism aging at cellular resolution (2023 Science). His current research focuses on applying single-cell sequencing technologies to understand aging, with the ultimate goal of improving human healthy lifespan. His achievements have been recognized by receiving several awards, including the Stanford Neuroscience Institute Interdisciplinary Award (2017), NIH K99/R00 Award (2019/2021), Cancer Prevention and Research Institute of Texas (CPRIT) Award (2020), Impetus longevity research Award (2021), Ted Nash Long Life Foundation Award (2022), and Welch Foundation Award (2023).
aging; genetics; model organism; longevity; senescence; health lifespan; aging clock; pro-longevity mechanisms
Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia
Assoc. prof. Dubravka Svob Strac, PhD, works as a Head of the Laboratory for Molecular Neuropsychiatry, Department of Molecular Medicine, Ruder Boskovic Institute, Zagreb. She received her MSc and PhD degrees in Molecular Biology at the Faculty of Science, University of Zagreb, and MSc degree in Project Management at Baltazar University, Zapresic. In addition to scientific work (95 papers, 22 book chapters, 2271 citations; h-index 26, 30 projects), she teaches at the Universities of Zagreb, Rijeka and Osijek (mentor of 18 MSc and 5 PhD students). She received several stipends and awards, including awards from Ruder Boskovic Institute, Department of Biotechnology University of Rijeka, and Croatian National Science Award.
neuropsychiatry; genetics; biomarkers; neuropharmacology
Population Health Department, University of Oxford, Oxford, UK
Cornelia M van Duijn is a Professor of Epidemiology at the Nuffield Department of Population Health of the University of Oxford. Her research within the Oxford Big Data Institute focuses on large-scale –omics studies of dementia and related disorders including vascular, endocrine, and gastrointestinal disease. Her current research portfolio includes cross-omics research integrating (epi)genetic, transcriptomic, proteomic, metabolomic and microbiome data of epidemiological cohorts with state-of-the-art brain imaging and cellular model systems. She co-leads the Dementia Research Oxford (DRO) consortium and is a member of the steering committee of the Oxford British Heart Foundation (BHF) Center of Excellence. Cornelia has been a leading figure in several international consortia including CHARGE (Cohorts for Heart & Aging Research in Genome Epidemiology), IGAP (International Genetics of Alzheimer Disease Project (IGAP) and EADB (European Alzheimer Disease Biobank). Over the years, she served on numerous scientific committees, including the European Research Council (ERC) Advance Research Grants committee. She is a member of the Supervisory Board member of the Lifelines study, the Senate of the German Centre for Neurodegenerative Diseases (DZNE) and the Scientific Advisory boards of the Finish Institute for Molecular Medicine (FIMM; chair) and France Genomique. Cornelia is a member of the Royal Academy of Arts and Sciences of the Netherlands (KNAW) and a fellow of the Academy of Medical Sciences (UK).
large-scale –omics studies of dementia and related disorders including vascular, endocrine, and gastrointestinal disease
1. Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford GU2 7XH, UK
2. Institute for People-Centred AI, University of Surrey, Guildford GU2 7X, UK
genetics; multi-omics; gut microbiome; metabolomics; neurodegenerative diseases; metabolic diseases; machine learning
Department of Human Sciences and Quality Life Promotion, San Raffaele Open University Rome and CEINGE Biotecnologie Avanzate, Naples, Italy
Valeria D’Argenio, MD, PhD, is Associate Professor of Clinical Biochemistry and Molecular Biology at the San Raffaele Open University of Rome (Italy), Principal Investigator (PI) at CEINGE Biotecnologie Avanzate of Naples (Italy), and Responsible for molecular diagnostics activities at CEINGE Biotecnologie Avanzate of Naples (Italy). The research activity of Prof. D'Argenio is in the field of translational research and medical biotechnologies, and is focused on technological innovations in laboratory medicine and their application to the study of the molecular basis of human inherited and acquired diseases, also for diagnostic purposes and in the field of personalized medicine. In this context, the activity of Prof. D'Argenio is aimed, also, at the technological transfer of traditional procedures to advanced ""omics"" techniques, such as next generation sequencing-based approaches. In recent years, she focused on the study of the human microbiome in health and disease status. Prof D’Argenio is author of more than 100 articles in international peer reviewed journals and has been invited speaker in more than 30 National and International Meetings in Clinical Biochemistry and Molecular Biology. Prof. D'Argenio received the ""Nunzio Pascale"" award for young researchers (2012), the SIBioC award for best presentation (2016), the ""Magna Grecia"" award 2021 and the ""Milano Cultura"" award 2022.
Genetics; Molecular Diagnostics; Molecular Oncology; Hereditary Breast and Ovarian Cancers; Translational Medicine
Thoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA
Dr. Gara is interested in exploring and identifying novel drug candidates and molecular pathways that are critical for initiation and progression of thoracic malignancies and eventually translate his research findings to develop new clinical trials in the branch that facilitate better outcomes for patients with these neoplasms. He employs wide varieties of techniques, methodologies and the state of art next generation sequencing in an induced pluripotent stem cell model of thoracic cancers. Additionally, he is passionate towards mentoring summer interns, postbacs and postdoctoral fellows in the branch.
cancer genetics; functional genomics; cell biology ;pharmacology ;structural biology immunotherapy
Faculty of Health, School of Biomedical Sciences, Centre for Genomics and Personalised Health, Queensland University of Technology, Australia
Professor Jyotsna Batra serves as a Laboratory Head and holds the position of Advance Queensland Industry Research Fellow at the Centre for Genomics and Personalised Health at Queensland University of Technology in Brisbane, Australia. With a background in Biochemistry leading to a Master’s degree and a PhD in Biotechnology focusing on the genetic complexity of hereditary disorders, Dr. Batra leads a research group dedicated to the molecular genetics of prostate cancer. Her current research emphasis revolves around identifying genetic variants associated with cancer risk and comprehending their molecular implications in cancer initiation and progression. Dr. Batra's goal is to develop improved biomarkers for early cancer detection and identify genetic markers capable of distinguishing slow-growing diseases from highly aggressive ones in the early stages. Dr. Batra has made substantial contributions, authoring over 200 research articles, including publications in prestigious journals such as Nature Genetics and Cancer Discovery (H-index 50). Dr. Batra has been a finalist for esteemed awards like ASMR and Women in Technology Leadership awards, winning the Qld Young Tall Poppy Award in 2019 and the Cure Cancer Researcher of the Year Award in 2018. Having secured over AUD 10 million in funding, she is currently funded by Advance Qld Industry Fellowship, DoD Idea Development grant, and MTPConnect REDI Fellowship (placement at TissueGnostics Vienna). Dr. Batra serves on the Editorial Board of Scientific Reports, Cancers, Genes, and several Frontiers Journals. In addition to her research and editorial roles, Professor Batra has served as the convenor or co-convenor for six national and international conferences. This leadership in organizing scientific gatherings further highlights her commitment to fostering collaboration, knowledge exchange, and advancements in the field.
Cancer, Genetics, transcriptomics, proteomics, biomarker
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
genome interpretation; protein coding variants; pathogenic effects; disease driver genes
psychiatric genetics; population genetics; personality genetics; genetics of depression
Nicholas K. Moschonas is Emeritus Professor of Medical Molecular Genetics, School of Medicine, U. of Patras, and Affiliated Scientist of the Institute of Chem. Engineering Sciences (ICE-HT), of the Foundation of Research and Technology (FORTH), Greece. He has studied biology, and evolutionary developmental biology at the U. of Patras, Natl. Kapodistrian U. of Athens, and Harvard U., and medical molecular genetics at the Natl. Inst. of Medical Res., MRC, London, UK. He teaches medical genetics, genomics, and molecular cell biology. He has served as faculty member and Professor of the Dept. of Biology, U. of Crete, head of the Human Molecular Genetics Laboratory (1984-2006) and collaborative faculty member of the Institute of Molecular Biology and Biotechnology (IMBB) of FORTH, and Professor (2006-2020) and chair of the Laboratory of General Biology of the School of Medicine, U. of Patras. N. Moschonas’ research interests are in medical molecular genetics and functional genomics with an emphasis on the study of the molecular architecture of genetic diseases in the light of the reconstruction and analysis of protein interaction networks. His research group had a longstanding contribution (1990-2004) to the Human Genome Project (HGP). He has served as principal investigator or head of research group in 11 international and 25 national competitive research programs. He has published more than 90 research and review articles in international journals including Cell, Nature, Proc. Natl. Acad. Sci., Mol. Cell. Biol., Devep. Cell, Bioinformatics, J. Biol. Chem., Nucl. Acid Res, Hum. Molec. Genet., Trends in Biochem. Sci., Biomolecules, etc. He is member of the Editorial Board of Human Genomics, and Genes (section Human Genomics and Genetic Diseases), and the Scientific Editor of the Greek edition of 8 university textbooks and 8 popular biology books. He has contributed to more than 250 international and national research Conferences, with more than 70 lectures as a guest speaker.
medical molecular genetics; genomics; protein interaction networks; network biology; molecular architecture of genetic diseases.
School of Biosciences and Medicine, University of Surrey. Edward Jenner Building 388 Stag Hill, GU2 7XH Guildford, UK
Faculty of Sciences and Technology, University of Coimbra, Calçada Martins de Freitas, Portugal
Isabel Henriques is an Associate Professor at the Department of Life Sciences, University of Coimbra, where she coordinates the PhD programme in Biosciences. She is a Researcher at the Centre for Functional Ecology, where she coordinates the Research Group One Health. Her area of specialization is Microbiology, and her research interests lie in Environmental Microbiology and Health. In the last decades she has been devoted to the study of antibiotic resistance ecology and of the role of microbiomes in the adaptation of organisms and ecosystems to global changes. She made important contributions to her field of research, published in 133 papers cited more than 5000 times. She is associate editor of BMC Genomics and Frontiers in Microbiology, and a member of the editorial board of Genes and Antibiotics.
One Health; Antimicrobial Resistance; Horizontal Gene Transfer; Environmental Microbiomes
Jianping (JP) Xu obtained his BSc from Jiangxi Agricultural University, MSc from Nanjing Agricultural University, and PhD from the University of Toronto. After postdoctoral training at Duke University, JP joined the faculty in the Department of Biology at McMaster University, first as Assistant Professor and subsequently promoted to Associate and Full Professor. His main research interest is in fungal genetics.
Mycology, Population Genetics, Genomics, Molecular Epidemiology
Keynote Speakers
UPJV HEMATIM UR 4666, C.U.R.S, Université de Picardie Jules Verne, CEDEX 1, 80025 Amiens, France
Nobel price attributed to microRNAs timeline of the discovery and summarize the inaugural papers of Ambros and Ruvkun
Molecular Biology and Biochemistry Department, Molecular Genetics Research Team (MGRT), Faculty of Biotechnology, German International University, 11835, Cairo, Egypt.
Liquid Biopsy-Guided Precision Immunotherapy: A special focus on LncRNAs in Young Breast Cancer Patients.
Institute of Molecular and Clinical Ophthalmology Basel (IOB), University of Basel, Mittlere Strasse 91, 4031 Basel, Switzerland
An integrated bioinformatic toolbox for the analysis of rare disease genetic data
Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 9190401, Israel
From gene cloning to mutation specific therapies in cystic fibrosis
Charles Bronfman Institute for Personalized Medicine, Department of Genetics and Genomic Sciences, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Novel Machine Learning Approaches for Predicting Functional Consequences of Human Genetic Variants
Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
Gut microbiome in infancy and childhood: a multiomic approach in health and disease
Population genomic analyses reveal diverse patterns of evolution in human fungal pathogens
Invited Speakers
Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran P.O. Box 19875-17411, Iran.
Consensus molecular subgroups (CMS) in colorectal cancer management.
Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15701 Athens, Greece.
The Combination of Sequencing Approaches Unravels the Post-transcriptional Regulatory Effect of Proteasome Inhibitors, in Breast Cancer.
Human Microbiomics Unit, Department of Medical and Surgical Sciences, University of Bologna, Bologna, 40138, Italy
Human Microbiome and Infections: (Not) Just the Two of Us
Registration
The registration for IECGE 2024 will be free of charge! The registration includes attendance to all conference sessions.
If you are registering several people under the same registration, please do not use the same email address for each person, but their individual university email addresses. Thank you for your understanding.
Please note that the submission and registration are two separate parts. Only scholars who registered can receive a link to access the conference live streaming. The deadline for registration is 6th December 2024.
Instructions for Authors
The 2nd International Electronic Conference on Genes will accept abstracts only. The accepted abstracts will be available online on Sciforum.net during and after the conference.
1. Deadline for abstract submission: 8th September 2024 30th September 2024.
2. Deadline for abstract acceptance notification: 22nd September 2024 14th October 2024. You will be notified of the acceptance of an oral presentation in a separate email.
Abstract submissions should be completed online by registering with www.sciforum.net and using the "New Submission" function once logged into the system. No physical template is necessary.
1. The structure abstract should include the introduction, methods, results, and conclusions sections of about 200–300 words in length.
2. All abstracts should be submitted and presented in clear, publication-ready English with accurate grammar and spelling.
3. You may submit multiple abstracts. However, only one abstract will be selected for oral presentation.
Detailed Requirements:
1. The submitting author must ensure that all co-authors are aware of the contents of the abstract.
2. Please select only one presenter for each submission. If you would like to change the presenter after submission, please email us accordingly.
Note: We only accept live presentations.
b. File format: PDF (.pdf).
c. Size in cm: 60 width x 80 height–portrait orientation.
d. Font size: ≥20.
e. Maximum size: 250 M
It is the authors' responsibility to identify and declare any personal circumstances or interests that may be perceived as inappropriately influencing the representation or interpretation of clinical research. If there is no conflict, please state "The authors declare no conflicts of interest." This should be conveyed in a separate "Conflict of Interest" statement preceding the "Acknowledgments" and "References" sections at the end of the manuscript. Any financial support for the study must be fully disclosed in the "Acknowledgments" section.
MDPI, the publisher of the Sciforum.net platform, is an open access publisher. We believe authors should retain the copyright to their scholarly works. Hence, by submitting an abstract to this conference, you retain the copyright to the work, but you grant MDPI the non-exclusive right to publish this abstract online on the Sciforum.net platform. This means you can easily submit your full paper (with the abstract) to any scientific journal at a later stage and transfer the copyright to its publisher if required.
Publication Opportunity
1. Genes Journal Publication
Participants in this conference are cordially invited to contribute a full manuscript to a Special Issue published in Genes (ISSN: 2073-4425, Impact Factor 2.8), with a 10% discount on the publication fee. All submitted papers will undergo MDPI’s standard peer-review procedure. The abstracts should be cited and noted on the first page of the paper.
Please note if you have IOAP/association discounts, conference discounts will be combined with IOAP/association discounts. Conference discounts cannot be combined with reviewer vouchers.
2. Proceeding Paper Publication
All accepted abstracts will be published in the conference report of IECGE 2024 in Biology and Life Sciences Forum (ISSN: 2673-9976); if you wish to publish an extended proceeding paper (4-8 pages), please submit it to the same journal after the conference.
Authors are asked to disclose that it is a proceeding paper of the IECGE 2024 conference paper in their cover letter.
Proceedings submission deadline: 10 February 2025
Carefully read the rules outlined in the 'Instructions for Authors' on the journal’s website and ensure that your submission adheres to these guidelines.
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Title.
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Full author names.
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Affiliations (including full postal address) and authors' e-mail addresses.
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Abstract.
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Keywords.
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Introduction.
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Methods.
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Results and Discussion.
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Conclusions.
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Acknowledgements.
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References.
Proceeding_paper-template.docx
List of accepted submissions (39)
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sciforum-105057 | The CXCR4/CXCL12 axis contributes to cerebrolysin-induced neuroprotection against staurosporine-treated cortical neurons at 7 days in vitro and prevents inflammation in a N2a cell line exposed to LPS |
Show Abstract |
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Introduction. Oxidative stress and inflammation are hallmarks of neurodegenerative diseases, including a reduced repair capacity. Neural progenitor cells (NPCs) from the subventricular zone (SVZ), the dentate gyrus and the olfactory bulb can migrate and differentiate into neurons or glial cells. CXCL12 chemokine binds to CXCR4 and this axis contributes to neuroinflammation. Following CNS insult, chemokines recruit stem cells for repair while the aberrant CXCR4 activation promotes cell death. In fact, NPCs, endothelial cells, neurons (and glia) express CXCR4, which enhance the homing of stem cells for neuronal repair. CXCL12 attracts neuroblasts and it is also secreted at sites of injury. Aim. This study evaluated whether cerebrolysin (brain porcine peptide) or recombinant chemokines may protect cortical neurons at 7 DIV against staurosporine-induced cell death or LPS-induced inflammation in a N2a cell line. For this purpose, extracts from cortical neurons or N2a cells were isolated and several inflammatory markers were quantified by pCR (IL-1 beta and CXCR4/SDF1 alpha). Staurosporine or LPS treatment were added during 6 hours in the medium and cerebrolysin or recombinant proteins were o/n added in the presence of these treatments. Results. The antiapoptotic role of chemokines and/or cerebrolysin was demonstrated in staurosporine-treated cortical neurons at 7 DIV using an XTT assay. Cerebrolysin prevented staurosporine-induced apoptosis in the N2A cell line and decreased Il-1 beta leveles in a N2a cell line exposed to LPS during 6 h. Conclusion. The observed correlation between cerebrolysin and the neuroprotective effect of chemokines against apoptosis suggests that CXCR4 chemokine receptor activation by cerebrolysin prevented staurosporine-induced cell death in cortical neurons from rats and also reduced IL-1 beta levels in a N2a murine cell line exposed to LPS (lipopolysaccharide)). Although the clinic efficacy of cerebrolysin against dementia requires more clinical evidences, some clinical trials have confirmed its efficacy against neurological diseases. |
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sciforum-106986 | Relevance of Pharmacogenomics, CYP450 genes and their genetic variations in drug metabolism and toxicity |
Surbhi Malhotra ,
Manik Kaushal ,
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Background: Variations in drug responses are related to inherited characteristics of the genome that cause a wide variability in individual responses to drugs. Pharmacogenetics or pharmacogenomics analyses help us to understand DNA variations that are related to drug action (pharmacodynamics) and drug disposition (pharmacokinetics). Using a pharmacogenomics (PGx) approach, we studied different CYP450 genes that are associated with drug metabolism, along with their genomic variants, thus strengthening our understanding of personalized medicines. Methods: We downloaded the PGx database from the FDA website and collated the data utilizing various evolutionary tools and software. We also provided an overview of current progress in computational approaches for the prediction of drug metabolism and toxicity using a combination of knowledge graph- and AI-based approaches. Utilizing ethnicity data from published sources, we also correlated the clinical implications of drug metabolism and toxicity variability in different population cohorts. Results: We observed that 42 unique drugs catering to nine different therapeutic areas are associated with six CYP450 (CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6 and CYP3A5) genes/biomarkers and 32 unique variants/SNPs. The allelic frequencies (AFs) of the 32 variants were also studied in different population ethnicity groups (from a published database). We observed unique combinations of drugs, biomarkers and variant associations that highlight how the metabolism of a drug is controlled/regulated/metabolized by the genetic basis of an individual. We observed 32 unique combinations where the same CYP biomarker and its variant are shared by different drugs associated with different therapeutic areas. Conclusions: PGx studies should be inclusive, and policy makers/drug regulators should include such approaches for better understanding the genetic basis of drug-metabolizing genes for better drug response. The PGx approach also highlights a significant association between Precision Medicine and Pharmacovigilance by understanding drug metabolism and toxicity in accordance with an individual’s genetic makeup. |
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sciforum-106255 |
Study of SUM159 Cell Lines Untreated and Treated with drug Mebendazole and its effect on Transcriptome Level (Rna-Seq Analysis)
, , Janhavi Tripathi ,
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,
Mrunal Gokhale ,
,
,
Debjani Dasgupta
Submitted: 04 Nov 2024 Abstract: Show Abstract |
,
,
Janhavi Tripathi ,
,
,
Mrunal Gokhale ,
,
,
Debjani Dasgupta
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Breast cancer is a leading cause of cancer-related deaths worldwide. While significant progress has been made in its diagnosis and treatment, it remains a major public health concern. This study aimed to investigate the transcriptomic effects of Mebendazole, an antiparasitic drug, on SUM159 cell lines, a model for triple-negative breast cancer (TNBC). RNA-Seq analysis was conducted to identify differentially expressed genes (DEGs) between untreated and Mebendazole-treated cells. Our analysis revealed significant transcriptional alterations in Mebendazole-treated SUM159 cells, with data collected from the NCBI GEO database. The GALAXY server NGS data analysis frame work was used, followed by FASTQC, FASTP, HISAT2, SAMTOOL_Sort, SAMTOOLs_Dataset, the Uploading GTF for Humans standard file from UCSC, Hiseq-Count and analysis in R-reported DEGs. The list of 820 DEGs were analysed for enrichment using EnrichR, David tools, to understand the involvement of DEGs in biological processes. DEGs were enriched in pathways related to cell cycle regulation, apoptosis, survival signaling, and metabolism, suggesting that Mebendazole exerts its effects through multiple mechanisms. Notably, the identified DEGs were associated with various diseases, including breast cancer and neurodegenerative disorders. The downregulated genes from the analysis reported to be involved in liver cirrhosis, atherosclerosis, neurological disorder, cellular adhesion, the extracellular matrix, the transcription factor, and the assembly of collagens in humans, whereas the upregulated genes were more involved in pathways of breast cancer, ovarian cancer, the cell cycle and the cell division process. These findings highlight the potential for Mebendazole to be repurposed as a therapeutic agent beyond its traditional use in parasitic infections. Further research is needed to validate these in vitro findings in vivo and explore the clinical implications of Mebendazole for cellular mechanisms, the signal cascade, TNBC and neurodegenerative diseases. |
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sciforum-106109 | RUNX1 Mutations in Stomach Adenocarcinoma: Unveiling a New Player in Solid Tumors and Its Immune Microenvironment Impact |
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Introduction: RUNX1, a transcription factor crucial for hematopoiesis and frequently mutated in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), has recently been implicated in solid tumors. This study investigates the role of RUNX1 mutations in stomach adenocarcinoma and their impact on the tumor immune microenvironment. Methods: Bioinformatic approaches using GEPIA (Gene Expression Profiling Interactive Analysis) and TIMER (Tumor Immune Estimation Resource) were used to analyze gene expression data and immune cell infiltration in stomach adenocarcinoma samples with and without RUNX1 mutations. Results: Stomach adenocarcinomas harboring RUNX1 mutations exhibited significantly higher levels of macrophage infiltration compared to wild-type tumors. Gene expression analysis revealed upregulation of key inflammatory mediators, including IFNG, TNF, IL1B, and NLRP3, in RUNX1-mutated samples. These findings suggest a strong association between RUNX1 mutations and an enhanced inflammatory tumor microenvironment. Conclusions: This study establishes a potential link between RUNX1 mutations, increased immune cell recruitment, and elevated expression of pro-inflammatory genes in stomach adenocarcinoma. This altered immune landscape may have important implications for disease progression and the development of targeted therapeutic approaches. Furthermore, these findings extend our understanding of RUNX1's role beyond hematological malignancies, highlighting its significance in solid tumors and opening new avenues for research and potential therapeutic interventions. |
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sciforum-107658 | The role of Iroquois-class homeobox genes in cancer stemness | , , |
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Introduction: Methods: Results: Conclusions: |
Event Awards
To acknowledge the support of the conference's esteemed authors and recognize their outstanding scientific accomplishments, we are pleased to announce that the conference will provide six awards including Best Oral Presentation Awards and Best Poster Awards.
The Awards
Number of Awards Available: 6
The Best Oral Presentation Awards are given to the submission judged to make the most significant oral contribution to the conference.
The Best Poster Awards are given to the submission judged to make the most significant and interesting poster for the conference.
There will be six winners selected for these awards. The winner will receive a certificate and 200 CHF each.
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A. Non-coding RNAs in Health and Diseases
Session Chair
Prof. Dr. Laurent Metzinger, UPJV HEMATIM UR 4666, C.U.R.S, Université de Picardie Jules Verne, France
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B. Genetic Diagnosis and Targeted Therapy in Cancer
Genetic diagnosis in cancer involves analyzing tumor DNA to identify specific mutations or genetic alterations that drive cancer progression, as well as analyzing the expression of cancer-related genes and other molecular biomarkers. This personalized approach helps with the classification of tumors based on their genetic profiles rather than just their tissue of origin. Targeted therapy then uses drugs designed to specifically inhibit these mutations or signaling pathways critical for cancer cell survival, such as HER2 inhibitors in breast cancer or BRAF inhibitors in melanoma. This precision medicine approach improves treatment efficacy, minimizes side effects, and offers tailored therapies directly addressing the genetic abnormalities unique to each patient's cancer.
Session Chair
Dr. Christos K. Kontos, Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, Greece
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C. Human Genomics and Genetic Diseases
Over the past two decades, the field of human genomics has undergone a technological revolution, leading to significant breakthroughs. These include a deeper understanding of disease etiology, gene and genome evolution, and the development of novel therapeutic approaches. However, alongside these advancements, new challenges and questions have emerged, requiring fresh perspectives and a re-evaluation of future genetic research strategies. In the "Human Genomics and Genetic Diseases" session, we will explore some of these key issues.
Session Chair
Prof. Dr. Dror Sharon, Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel
D. Technologies and Resources for Genetics Research
Session Chair
Prof. Dr. Maria Luisa Chiusano, 1. Department of Agriculture, University of Naples Federico II, Portici, 80055 Naples, Italy; 2. Department of Research Infrastructures for Marine Biological Resources, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
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E. Microbial Genetics and Genomics
Session Chair
Dr. Silvia Turroni, Department of Pharmacy and Biotechnology, University of Bologna, Italy
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