We report the improved synthesis of the antiviral 6-fluoro-3-hydroxy-pyrazine-2-carboxamide (T-705).

Chalcones and their heterocyclic analogues are known to possess a broad spectrum of biological effects. The present study is devoted to the synthesis of 3,4- Dimethoxy-2'-Hydroxy-5'-methyl chalcone and its derived products i.e. flavanone, flavonol, flavone, aurone, isoxazoline, chalconeimine and acetoxy chalcone. These newly synthesized compounds were screened for their antibacterial and anti-fungal activities.

A great deal of work has been done on the synthesis of oxazolones. We have obtained 5(4H)-oxazolones by condensing anthracene-10-carbaldehyde & furan-2- carbaldehyde with a number of substituted benzoyl glycines, and tried to design new and effective anti-bacterial agents.

Enantiomerically pure substituted 1,4-dioxanes have been prepared from vinyl phenyl selenones and the commercially available enantiopure 1,2-diols in the presence of sodium hydride. This simple and novel one step procedure is an example of the Michael initiated ring closure reactions (MIRC) and involves a conjugate addition of the alkoxide anions derived from the 1,2-diols to the vinyl phenyl selenones. The carbanions thus generated then suffer a proton transfer to give the alkoxide ions which effect the intramolecular displacement of the PhSeO2 group affording the substituted 1,4-dioxanes as the result of a ring closure reaction.

3 equivalents of ammonium persulfate in a 3:1 mixture of MeCN and water slowly convert alkynes into the corresponding 1,2-dicarbonyl compounds. The oxidation rate is enhanced by the presence of diphenyl diselenide that form in situ the electrophilic PhSeOSO3H able to promote a "one pot" hydroxyselenenyilation-deselenenylation reaction.

Microwave assisted formation of C-Te bonds is applied to the preparation of p-methoxyphenyltellurium trichloride in a fast, direct and simple way.

Liquid crystal monomers and polymers containing fluorinated alkyl chain have been prepared. The polymerization initiated by [Rh(nbd)Cl]2 has afforded the products in moderate to high yields. The molecular weight of polymers has been measured with gel permeation chromatography (GPC), the results show that the transition metal catalyst in THF/Et3N solvent system gives the best results for the polymerization. Monomers and polymers are characterized by IR and 1HNMR, and the liquid crystalline properties are evaluated by using POM, DSC and TGA. The results show that the monomers with fluorinated chain and polymers show SmA phase. The fluorinated polymers possess higher clearing points and broader mesophases than the alkyl chain polymers.

Cellulose from cotton was modified through reaction of sodium carboxymethyl cellulose (NaCMC) with diethanolamine and an epichlorohydrinethylendiamine system in molar ratios of 1:1.5:1.5; 1:2:2; 1:3:3 and 1:4:4, respectively. The modification with epichlorohydrin-ethylendiamine was carried out in two steps: in the first step, NaCMC was reacted with epichlorohydrin, and in the second step, oxiran-2-ylmethyl carboxy-methylcellulose reacted with ethylendiamine gave cellulose-g-epichlorohydrin/ ethylendiamine. The surfaces of the obtained products have been investigated by SEM images. Their adsorption capability for Pb2+, Cd2+ and Mn2+ ions (at concentrations of 10,000, 2,000, 1,000, 600, 400 and 100 ppm) have been investigated.

Cellulose was modified with citric acid in high temperature. Investigations of its absorption of heavy metal ions (such as Pb2+ and Cd2+) showed that modified cellulose in conditions 120°C and 12 h and in mass ratio of cellulose :citric acid=1:3 had highest absorption capacity. Absorption capacity of modified cellulose increased in accordance with increase of concentrations of ions. Structure of modified cellulose was confirmed by IR spectra and SEM pictures.

Cellulose was modified by reaction with (N‐butyl‐N‐chloropropyl‐N,N‐dimethyl) ammonium bromide (BCDMAB). The optimum reaction conditions were as follows: temperature 55°C, reaction time 3.2 h and mass ratio of cellulose:BCDMAB=1:2.5. Equilibrium adsorption capacity of modified cellulose for arsenate ion has been estimated. It's shown that this capacity increased with concentrations of arsenate ion. Structure of modified cellulose was confirmed by IR and SEM images.