3-​Chloromethyl oxacephem as a 5-oxa-1-azabicyclo[4.2.0]oct-2-en-8-one heterocycle displayed the potent antibacterial activity against both Gram-positive and Gram-negative bacteria. Importantly, it can be used as a starting material to synthesize Latamoxef and Flomoxef. However, the industrial route of 3-​chloromethyl oxacephem is trival and low yielding. Therefore, discovery a Simple and productive synthetic method is very necessary. The inexpensive 6-Aminopenicillanic acid was used to obtain the 3-​chloromethyl oxacephem in our group.

Treatment of breast cancer is not easy because of the complexity in molecular physiology. Surgery, chemotherapy and radiation therapy includes different sources of treating breast cancer. The systemic chemotherapy faces lot of challenges, mainly adverse effects. So, there is a need of newer drugs to be developed against breast cancer. The present work tries to justify the folklore claims of Tabernaemontana divaricata (L.) R. Br. ex Roem. & Schult. through a sound scientific background using modern analytical tools. It was found that phytoconstituents of the plant showed good docking score against 3ERT protein. The petroleum ether extract and chloroform extract showed anticancer activity. Petroleum ether extract was found to have GI₅₀ value of 18.7µg/ml. Phytochemical Studies lead to the isolation of two compounds, 1 and 2. These compounds, isolated from the leaves were studied and characterized tentatively with the help of modern analytical tools like FTIR, ¹H NMR and MS. Based upon spectral studies, compound 1 was characterized as 2-(1,6a,6b,9,9,12a,14b-heptamethyl 1, 2, 4a, 5, 6, 6a, 6b, 7, 9, 10, 11, 12, 12a, 12b, 13, 14b-hexadecahydropicen-3-yl) propan-2-yl nonanoate. Compound 2 was found to be not pure enough to be characterized. The isolated compounds were also tested for their anti-proliferative activity against breast cancer.

Recently, barium ferrite nanoparticles have attracted substantial attention because of widespread applications in catalytic degradations, credit cards, storage hardwares, sensors, microwave devices, permanent magnets, high frequencies, photocatalytic catalysts, and etc. In this research, templated BaFe₁₂O₁₉ nanoparticles were prepared through the sol-gel method by use of cotton as a template in the sol step. Finally, templated nanoparticles were blended in the silicone rubber matrix and then prepared nanocomposite molded to investigate of microwave absorption properties at x-band frequency. Templated barium hexaferrite nanoparticles were characterized by Fourier transform infrared (FT-IR), diffuse reflection spectroscopy (DRS), vibrating sample magnetometer (VSM), field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), and microwave absorption characteristics were obtained by vector network analyzer (VNA). Microwave absorption curves showed that Templated BaFe₁₂O₁₉/silicone rubber nanocomposite absorbed 65.80% of microwaves at 9.87 GHz.

Surfactants are compounds that lower the surface tension between surfaces. They are usually organic compounds that are amphiphilic, able to control the size and morphology of nanoparticles. In this study, silver nitrate and oxalic acid are used to prepare an inorganic complex in the presence or absence of surfactant, CTAB. The main characterization methods were FTIR and SEM.

It can be observed from SEM images that the synthesized complexes have various particle sizes including nano sizes by adding the surfactant. The prepared complexes were calcinated to obtain the corresponding oxide, Ag₂O with different particle sizes and morphologies. The surfactant can effect on size and morphology of both silver complex and silver oxide.  

The high level of production and use of dyes due to industrialization has created a great global environmental concern. These pollutants are non-biodegradable and stable to light, heat, and moderate oxidizing agents which create the serious threats to human health and marine. Hence, removal of these pollutants from discharged wastewater is a very challenging task. The aim of this present study was to utilize the residual biomass of corn for eco-friendly bioadsorbent preparation and eliminating the methyl orange from aqueous solution. The effects of initial dye concentration, bioadsorbent dosage and contact time on the adsorption capacity of the bioadsorbent were investigated. The maximum adsorption capacities of the bioadsorbent for methyl orange was 350 mg g^-1 at initial concentration of 500 mg L^-1. Moreover, the recyclability experiments demonstrated that the bioadsorbent could be reused for at least four cycles with stable adsorption capacity. These results provide that corn cob based bioadsorbent can be utilize as an effective adsorbent for practical wastewater treatment.

Atmospheric contamination from ionic liquids (ILs) is very improbable due to the low vapour pressure of these compounds. Nevertheless many ILs are water soluble and they can generate harmful effects on aquatic organisms, soils and plants.

Inhibition of bioluminescence of Vibrio fischeri bacteria is one of the most used tests to determine the toxicity of ILs, however these results cannot be extrapolated to other trophic levels. Germination and early growth tests are very commonly used in ecotoxicology studies because of their sensitivity to environmental contamination.

This work presents the main conclusions of a study of early growth of Eucalyptus globulus Labill plants on two forest soils with different pH (one acidic and one calcareous) and spiked with five different amounts of aqueous solutions of [BMIM][BF₄] (0, 1.2, 3, 12 and 30 g·kg^-1 dry soil). Six plants of E. globulus were slightly introduced into the soil surface. Quadruplicate samples for each soil and [BMIM][BF₄] dose were prepared, and the pots with soils were placed in a growth chamber with photoperiod at 25 °C, ambient humidity of 60% and light/dark cycles of 16/8 h for 2 weeks. The stems and roots length, the leaf number and the dry weight were determined in every case.

The addition of [BMIM][BF₄] had important effects on the survival and early growth of plants characterized by a decrease with the increasing IL concentration, and for doses higher than 10% the total mortality was observed for both soils. The decrease observed on the survival and early growth of E. globulus plants was lower in the calcareous soil than in the acidic soil.

Eight novel 2-aminonitrile oxazoles were synthesized efficiently and quickly via the Ugi reaction in its three-component version in moderate to good yields (55-82%) at room temperature or in good to excellent yields (70-96%) using ultrasound irradiation (USI) as heat source. It is noteworthy that not only the yields were improved by using USI, also the reaction times decreased considerably, from 6-10 hours (at r.t.) to 1-2 hours (USI), depending on the substituents. The final products are highly functionalized molecules because they contain an amino group, a nitrile group, an oxazole group and a very reactive biaryl-benzylic position. In this context, they can be used for further condensations, cyclizations and/or functionalizations toward a variety of compounds with potential applications in several fields of knowledge like optics, material science and medicinal chemistry. All products were fully characterized by spectroscopic techniques (H and C-NMR, IR and HRMS), even by mp and Rf.

Hollow zirconium ferrite cauliflowers were synthesized by a facile solvothermal method using ultrasonic waves. The prepared nanoparticles were employed for the removal of methylene blue (MB) in the wastewater treatment. X-ray diffraction (XRD) pattern of the ferrite sample is well in agreement with the standard pattern of the ZrFe₂O₄ structure. Scanning electron microscopy (SEM) image reveals that the resultant ferrite is nanoporous structurally and the average sizes of spheres and holes diameter were measured at 150 and 20 nm, respectively. The magnetic properties of the hollow nanospheres were characterized on a vibrant sample magnetometer (VSM) with maximum saturation magnetization value of 70.3 emu/g. UV-visible absorption spectroscopy was used to record the adsorption behavior. The maximum adsorption capacity of magnetic hollow ZrFe₂O₄ cauliflowers for MB in the concentration range (1–50 mg L-1) studied, as calculated from the Langmuir isotherm model.

It has been frequently said that onset temperatures obtained from dynamic thermogravimetric analysis can be used to estimate the short-term thermal stability of materials and also the relative thermal stability [1-3].

In this work the relative thermal stability was studied through dynamic analysis under the same experimental conditions for 50 Ionic Liquids (ILs). Several families with fixed anions and different cations and vice versa were chosen to have a comprehensive knowledge of thermal properties of ILs depending on the ions selection. Non-isothermal scans were performed under air atmosphere and a heating rate of 10 K · min^-1 for all the selected ILs.

It was observed that the anion influence on the thermal stability is stronger than the cation one, being ILs with [NTf₂]^- and [OTf]^- anions the most stable; meanwhile dicyanamide, nitrate and acetate based ILs were the least stable.

Discovering drugs to a disease is still a challenging task for researchers due to the complexity of biomolecules involved in pathologic processes. Design and development of new and more efficient drugs is still urgent for several diseases. Cheminformatics tools are useful to better understand the complex structures of chemical compounds and the implication of chemical features in the activity. In the current work, a series of synthetic 3-arylcoumarins, with reported antioxidant activity, was studied. A virtual screening, based on the TOPSMODE approach, using a clastogenic model, was performed to predict the potential genotoxicity of the studied molecules. A preliminary interpretation of the relationship between structure and clastogenicity suggests the importance of hydroxyl groups at positions 7 and/or 8 of the coumarin ring. This communication is focused on cheminformatics and its applications on drug discovery, helping to find solutions to complex diseases.