A Coupling-Isomerization Sequence As An Entry To A Novel Three Component One-Pot Synthesis of 1,5-Benzoheteroazepines

Thomas Müller; Roland Baum

doi:10.3390/ecsoc-4-01855

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A Coupling-Isomerization Sequence As An Entry To A Novel Three Component One-Pot Synthesis of 1,5-Benzoheteroazepines

Thomas J. J. Müller

^*,

Roland U. Baum

¹ Department Chemie, Ludwig-Maximilians-Universitat München, Butenandtstr. 5-13 (Haus F), D-81377 München, Germany

Published: 11 September 2000 by MDPI in The 4th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-4-01855

Abstract: 2,4-Di(hetero)aryl substituted 2,3-dihydro 1,5-benzodiazepines, -oxazepines, and thiazepines can be readily synthesized in a three component one-pot process initiated by a coupling-isomerization sequence of an electron poor (hetero)aryl halide and a terminal propargyl alcohol subsequently followed by a cyclocondensation with 2-amino, 2-hydroxy, or 2-mercapto anilines.

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Thomas Müller

Roland Baum