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Functionalized Organolithium Compounds Through an Arene-Catalyzed Lithiation
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1  Departamento de Química Orgánica, Universidad de Alicante. E-03080 Alicante, Spain

Abstract: Naphthalene- or DTBB-catalyzed lithiation of chloroimines 1, deprotonated chlorobenzyl alcohols, mercaptanes or amines 4, and 3-phenylthiopropylamine 7 in THF at -78deg.C leads to the formation of the corresponding intermediates 2, 5 and 8, which by reaction with carbonyl compounds as electrophiles afford the expected bifunctionalized compounds 3, 6 and 9, respectively.
Keywords: Fuctionalized organolithiums, arene-catalyzed lithiation

 
 
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