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Synthesis and Cytotoxic Evaluation of Constrained Analogues of Combretastatin and Combretastatin A4.
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1  Université Lille Nord de France, F-59000 Lille, France
2  USTL, Laboratoire de Chimie Organique Physique, EA CMF 4478, Bâtiment C3(2), F-59655 Villeneuve d'Ascq, France
3  CNRS, UMR 8181 'UCCS', F-59655 Villeneuve d'Ascq, France

Abstract: A series of cis-locked stilbenic compounds related to combretastatin and combretastatin A4 has been designed and synthesized. The cytotoxic effects of these rigid analogues were evaluated as well as their abilities to inhibit tubulin polymerization.
Keywords: combretastatins, isoindolinones, oxygen heterocycle, oxidation, anticancer agents.

 
 
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