Abstract: Several ionic liquids used as catalyst for three-component Mannich reactions of aldehydes, amines, and naphthols at room temperature. The used ionic liquids include 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF₄), 1-octyl-3- methylimidazolium tetrafluoro-borate ([Omim]BF₄), 1-ethyl-3-methylimidazolium tetrafluoroborate ([Emim]BF₄), butyl dimethylimidazolium tetrafluoroborate ([Bdmim]BF₄), 1-octyl-3-methylimidazolium nitrate ([Omim]NO₃), 1-methylimidazolium sulfuric acid ([Hmim]HSO₄) and 1-methylimidazolium trifluoroacetic acid ([Hmim] Tfa). Higher yields were obtained in the presence of [Hmim]Tfa in comparison with other ionic liquids.