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Fix-Wavelength Multi-Analyte Detection with serial SOI Ring Resonators
* 1 , 1 , 1 , 2 , 1
1  Department of High Frequency Technology/Photonics, Technische Universität Berlin, Einsteinufer 25, 10587 Berlin, Germany
2  Institute of Medical Immunology, Charité—Universitätsmedizin Berlin, Lindenberger Weg 80, 13125 Berlin, Germany

Published: 17 May 2021 by MDPI in 8th International Symposium on Sensor Science session Chemical Sensors (registering DOI)

We present a method for the read-out of five serially arranged SOI ring resonator-based biosensors at a speed of 3 Hz/sensor and at a fixed wavelength of 1550 nm. The system uses the high thermo-optical coefficient of silicon by applying AC voltages to periodically heat up electrodes adjacent to each sensor. A time-division multiplex scheme allows the allocation of the measured optical output from the mutual spectrum to each specific resonator. We demonstrate our system by immobilizing two different antibodies (biotin and a hexa-His-peptide) at the surface of selected resonators and successfully showing the selective binding characteristics of analyte-probing in a microfluidics supported experiments.

Keywords: biosensors; ring resonators; silicon-on-insulator; thermo-optical tuning; sensor multiplexing; microfluidics