We evaluated the minimum concentration and minimum size of magnetic particles (MPs) within which modern ultra-sensitive magnetic field sensors (MFS) can detect them. Calculations showed that magnetite MPs with specific magnetization with characteristic sizes of ≥50 nm and a concentration of CV ~ 0.1 vol.% Can be detected at a distance l ≤ 0.1 mm using MFS with a magnetic field resolution of SB ≥1nT. However, at such a close distance it is impossible to non-invasively approach the biological object of study. On the other hand, the same MPs are easily detected at l ≤ 30 mm using supersensitive MFS based on the phenomena of superconductivity (SQUID) or superconductivity and spintronics (combined MFS (CMFS)). These sensors require cryogenic operating temperatures (4–77 K), and SB ~ 10–100 fT are realized in them. Note that superparamagnetic particles or carbon nanotubes (CNTs) can also be non-invasively detected by SQUID or CMFS sensors, assuming that their concentration in the material is CV ≥ 0.0000001 vol.%. It is believed that CNTs may contain catalytic iron particles or encapsulated magnetic nanoparticles in nanotubes. Thus, modern supersensitive magnetic field sensors with SB ≤ 100 fT make it possible to detect MPs in nanoscale, submicron, and micron sizes in biological objects. They can be used for non-invasive control of organs, implants, prostheses and drug carriers in the necessary parts of the body. Particularly important is the non-invasive control of CNTs in functional biocompatible nanomaterials, which have good prospects for widespread use in medical practice.
Previous Article in event
Next Article in event
Next Article in session
Next Article in panel
Possibility Non-Invasive Detection Magnetic Particles in Biological Objects
Published:
17 May 2021
by MDPI
in 8th International Symposium on Sensor Science
session Nano(bio)Sensors and Bioelectronics
https://doi.org/10.3390/I3S2021Dresden-10137
(registering DOI)
Abstract:
Keywords: magnetic particles; magnetic field sensor; magnetic field resolution; carbon nanotubes