When considering a disorder without tumor redox metabolism, a highlight is glioblastoma multiforme. These are malignant tumors originating in astrocytes and oligodendroglia, highly aggressive and of rapid development, and for that reason the death can occur in a few months after the diagnosis. The study aims to expose an overview of the potential of physical activity against the redox system in glioblastoma multiforme. A narrative review used as a method to expose a pertinent appreciation of the topic. To initiate an investigation, a guiding question was elaborated for the conduct of the research process, which occurred in electronic databases, such as Pubmed Central, Scielo and Scopus. Answers to the question "what is the influence of physical exercise on the redox metabolism of glioblastoma multiforme?" Were chosen to compose the final sample of studies. The results reveal that knowledge of oxidative stress processes against glioblastomas can provide insights into the different managements that slow the progress of the disease and decrease its morbidity and mortality. A positive regulation of mRNA from antioxidant enzymes was corrected, suggestion of autophagy, damaging an anti-invasive effect of the tumor. However, other authors did not observe a reduction in the tumor. Although divergent, the information is promising for the clinical management and quality of life of patients.