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Parallel Kinetic Resolution of 1-Phenylethanol Using Quasi-Enantiomeric Active Esters
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1  Department of Chemistry, The University of Hull, Cottingham Road, Kingston upon Hull, UK HU6 7RX

Abstract: Parallel Kinetic Resolutions (PKRs) involves the parallel separation of enantiomers under kinetic control. We have recently reported the parallel kinetic resolution of racemic oxazolidinone (rac)-4 using a combination of quasienantiomeric active esters (S)-5 and (R)-6. These processes proceeded efficiently to give separable diastereoisomeric adducts (S,R)-syn-7 and (R,S)-syn-8 in good yields with excellent levels of stereocontrol (>90% d.e.).
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