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Reductions of Monosaccharide Derivative Epoxyamides to Epoxyalcohols and Regioselective Epoxide Opening
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1  Departamento de Bioquímica, Biología Molecular y Química Orgánica, Facultad de Ciencias.Universidad de Málaga. 29071 Málaga. Spain

Abstract: Amide group reduction in monosaccharide derivative 2,3-epoxyamides were accomplished with a combination of two reagents: RedAl and NaBH4, successively added at 0ºC, without affecting the epoxide group. The obtained epoxyalcohols could be regioselectively opened at the vicinal carbon to the hydroxymethyl group, by NaN3/Me3B without detection of another azido isomer.
Keywords: n/a