Previous Article in event
Next Article in event
Reductions of Monosaccharide Derivative Epoxyamides to Epoxyalcohols and Regioselective Epoxide Opening
Published: 10 November 2008 by MDPI in The 12th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: Amide group reduction in monosaccharide derivative 2,3-epoxyamides were accomplished with a combination of two reagents: RedAl and NaBH4, successively added at 0ºC, without affecting the epoxide group. The obtained epoxyalcohols could be regioselectively opened at the vicinal carbon to the hydroxymethyl group, by NaN3/Me3B without detection of another azido isomer.