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Application of Suzuki Coupling Reaction for Preparation of Some Arylchrysin Analogues
* 1 , 2
1  Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Dinh Tien Hoang, Dist. 1, Ho Chi Minh City, Vietnam
2  Department of Medicinal Chemistry, School of Pharmacy, Kangwon National University, Chuncheon 200-701, South Korea

Abstract: A new class of flavone which possess an aryl radical substituted in the A ring via C-C bond, arylchrysin analogues, has been synthesized from chrysin by Suzuki coupling reaction in three to five steps. Firstly, methylation or benzylation reaction was applied on chrysin to protect hydroxyl phenol moiety. Then, halogenation by iodine or bromine in anhydrous acetic acid was performed to obtain halogenated chrysin. Finally, intermediate compounds were treated with areneboronic derivatives catalyzed by palladium tetrakits to generate arylchrysin analogues with high yields.
Keywords: arylchrysin, carbon-carbon coupling Suzuki reaction