Commonly used antibiotics use multiple administrations for providing a continuous bactericidal effect but can increase systemic toxicity, as well as lead to bacterial drug resistance [1,2]. The use of plant-based antibacterial compounds in combination with conventional antibiotics to treat drug-resistant infections could be an alternative to overcoming the problem of bacterial resistance . The combination of antibiotics with plant-based antibacterial compounds has been shown synergistic advantages due to the inhibition of drug efflux and the presence of alternative mechanisms of action . Moreover, the nanoencapsulation of antibiotics is another effective technique to overcome antibiotic resistance . Nano-encapsulated antimicrobials have a better performance in comparison with traditional antibiotics due to their small size which leads to better interaction with bacterial cells . The different nanocarriers are effective in efficiently administering antibiotics by improving pharmacokinetics and accumulation while reducing the adverse effects . Additionally, the surface engineering of nanocarriers provides benefits such as targeting and modulating various resistance mechanisms . Furthermore, most nanocarriers are suitable platforms for co-loading of plant-based antibacterial compounds and traditional antibiotics to provide synergistic effects . This study outlines recent attempts to combat infectious diseases, with a focus on the use of plant-based nanoantibiotics as novel tools to address today's issues in infectious disease treatment.
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