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An Easy Synthesis of 5-Nitro-Thiophenes and 3-Amino-2-Nitro-Thiophenes
Published: 30 November 2007 by MDPI in The 11th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: A one-step preparation of substituted 5-nitro thiophenes and 3-amino-2-nitrothiophenes starting from corresponding β-chloroacroleins and β-chloropropenonitriles was developed. Sodium sulfide, bromonitromethane and sodium hydroxide were used as reagents to obtain the expected compounds in good yields with a simple and easy work up procedure.