Isoprene-mediated lithiation of chiral N-alkylimidazoles

Rosario Torregrosa; Isidro Pastor; Miguel Yus

doi:10.3390/ecsoc-11-01302

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Isoprene-mediated lithiation of chiral N-alkylimidazoles

Rosario Torregrosa

Isidro M. Pastor

Miguel Yus

¹ Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain

Published: 30 November 2007 by MDPI in The 11th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-11-01302

Abstract: The isoprene-mediated lithiation of different chiral N-alkylimidazoles (2a and 2b) and the following reaction with pivalaldehyde leads to the corresponding imidazolylpropanol derivatives 4 and 5 with excellent overall yield, but low de (up to 26%).

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Rosario Torregrosa

Isidro Pastor

Miguel Yus