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Isoprene-mediated lithiation of chiral N-alkylimidazoles
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1  Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain

Abstract: The isoprene-mediated lithiation of different chiral N-alkylimidazoles (2a and 2b) and the following reaction with pivalaldehyde leads to the corresponding imidazolylpropanol derivatives 4 and 5 with excellent overall yield, but low de (up to 26%).

 
 
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