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Stereoselective Synthesis of Thiaerythrinanes via Parham Cyclisation
Published: 30 November 2007 by MDPI in The 11th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: Parham cyclisation – intermolecular α-amidoalkylation sequence constitute a route to trans thiazolo[4,3-a]isoquinolinones. These thiazolidindiones, that incorporate allyl groups at C-1 and C-10b, are efficient precursors of thiaerythrinanes by ring-closing methathesis reactions.
Keywords: Lithiation, lithium-halogen exchange, α-amidoalkylation, Parham cyclisation, heterocycles, thiareythrinanes