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Heterocyclic Synthesis with Nitriles: Synthesis of Pyridazine and Pyridopyridazine Derivatives
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1  Centro de Química, IBQF, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal

Abstract: The reaction of MND with aryldiazonium chlorides followed by cyclization afforded the pyridazinimine derivatives. Reaction of the latter with another mole of malononitrile produce only pyrido[3,2-c]pyridazine derivatives. Reaction of 4-aminopyridazinone-3- carboxylix acid esters with malononitrile gave only pyridazine-3-carboxylic acid.
Keywords: n/a