Heterocyclic Synthesis with Nitriles: Synthesis of Pyridazine and Pyridopyridazine Derivatives

Abdellatif Salaheldin; Lígia Rodrigues; Ana Oliveira-Campos

doi:10.3390/ecsoc-11-01319

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Heterocyclic Synthesis with Nitriles: Synthesis of Pyridazine and Pyridopyridazine Derivatives

Abdellatif M. Salaheldin

^*,

Lígia M. Rodrigues

Ana M. F. Oliveira-Campos

¹ Centro de Química, IBQF, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal

Published: 30 November 2007 by MDPI in The 11th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-11-01319

Abstract: The reaction of MND with aryldiazonium chlorides followed by cyclization afforded the pyridazinimine derivatives. Reaction of the latter with another mole of malononitrile produce only pyrido[3,2-c]pyridazine derivatives. Reaction of 4-aminopyridazinone-3- carboxylix acid esters with malononitrile gave only pyridazine-3-carboxylic acid.

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Abdellatif Salaheldin

Lígia Rodrigues

Ana Oliveira-Campos