Please login first
Antimicrobial activity and DNA/BSA binding affinities of silver(I) and gold(III) complexes with 1,6-naphthyridine
* 1 , 2 , 3 , 2 , 4 , 3
1  University of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science, Jovana Cvijića bb, 34000 Kragujevac, Serbia
2  University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 444a, 11042 Belgrade, Serbia
3  University of Kragujevac, Faculty of Science, Department of Chemistry, R. Domanovića 12, 34000 Kragujevac, Serbia
4  Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade, Serbia
Academic Editor: Alfredo Berzal-Herranz (registering DOI)

Silver(I) and gold(III) complexes with aromatic nitrogen-containing heterocycles have shown an effective and wide-spectrum antimicrobial activity. The possible mechanism of their antimicrobial activity can be attributed to the interactions of these complexes with biomolecules, including DNA and proteins. In the present study, new silver(I) complex with 1,6-naphthyridine (1,6-naph), {[Ag(1,6-naph)(H2O)](BF4)}n (1) was synthesized and characterized by NMR, IR and UV-Vis spectroscopy, and its crystal structure was determined by single-crystal X-ray diffraction analysis. The complex 1 and the previously reported analogue gold(III) complex [1], [AuCl3(1,6-naph)], were evaluated for antimicrobial activity against the panel of representative microorganisms, while their cytotoxicity was tested against normal human lung fibroblast cell line (MRC-5). The binding affinity of these complexes with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to clarify the mode of their antimicrobial activity.

Keywords: Silver(I) complexes; Gold(III) complexes; 1,6-Naphthyridine; Antimicrobial activity; DNA/BSA interaction.