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-7α-Alkoxyestra-1,3,5(10)-trienes
Thies Thiemann
* 1 ,
Keiko Ideta
2 ,
Goreti R. Morais
3 ,
Cristina Oliveira
4 ,
Yuji Shima
1 ,
Takumi Yasuda
1
1  Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, 6-1, Kasuga-koh-en, Kasuga-shi, Fukuoka 816-8580, Japan
2  Institute of Materials Chemistry and Engineering, Kyushu University, 6-1, Kasuga-koh-en, Kasuga-shi, Fukuoka 816-8580, Japan
3  Faculty of Pharmacy, University of Lisbon, Av. das Forcas Armadas, P-1649 Lisbon, Portugal
4  Química Inorgânica e Radiofarmacêutica, Instituto Tecnológico e Nuclear, Estrada Nacional 10, Apartado 21, P-2686-953 Sacavém, Portugal
Published: 30 November 2007 by MDPI in The 11th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
https://doi.org/10.3390/ecsoc-11-01329
Abstract: A number of a-alkoxyestradiols were prepared through LiAlH 4 reduction of a suitably protected 6a,7a-epoxyestra-1,3,5(10)-trien-3-ol-17-one, alkylation of the resultant 7a-hydroxyestra-1,3,5(10)-trien-3-ol-17-one derivative and subsequent transformation of the C17 functionality. The stereochemistry of the products was investigated by 2D NMR spectroscopy.
Keywords: steroids, steroidal ethers, estradiol, estrogen, breast cancer
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