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-7α-Alkoxyestra-1,3,5(10)-trienes
Published:
30 November 2007
by MDPI
in The 11th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract: A number of a-alkoxyestradiols were prepared through LiAlH 4 reduction of a suitably protected 6a,7a-epoxyestra-1,3,5(10)-trien-3-ol-17-one, alkylation of the resultant 7a-hydroxyestra-1,3,5(10)-trien-3-ol-17-one derivative and subsequent transformation of the C17 functionality. The stereochemistry of the products was investigated by 2D NMR spectroscopy.
Keywords: steroids, steroidal ethers, estradiol, estrogen, breast cancer