Previous Article in event Previous Article in session
Next Article in event
Synthesis of (HET)ARYLAMIDOGUANIDINES and their Anticoagulant Activity Evaluation
Published: 30 November 2007 by MDPI in The 11th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products
Abstract: (Het)arylamidoguanidines were synthesized from corresponding hydrazides and S-methyl isothiourea. They were screened in vitro for anticoagulant activity using whole canine blood. The most active compounds, namely 4-methylbenzamidoguanidine and nicotinamidoguanidine were also tested on platelet free plasma. No effect was observed for these compounds on the clotting time of platelet free plasma. Therefore, platelets were suspected as a possible target for the anticoagulant activity of the (het)arylamidoguanidines.