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Photocleavage Studies of γ-aminobutyric acid (GABA) Conjugates
Published:
30 November 2007
by MDPI
in The 11th International Electronic Conference on Synthetic Organic Chemistry
session Bioorganic Chemistry and Natural Products
Abstract: Polycyclic aromatic labels such as naphthalene and pyrene were coupled to the C- terminus of N-benzyloxycarbonyl protected -aminobutyric acid (GABA). The photophysical properties of the corresponding fluorescent conjugates were evaluated, as well as their behaviour towards photocleavage by irradiation in MeOH/HEPES buffer solution (80:20), in a photochemical reactor at different wavelengths (254, 300, 350 and 419 nm), followed by HPLC/UV monitoring.
Keywords: Naphthalene; Pyrene; -Aminobutyric acid (GABA); Photocleavable protecting groups
