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Photocleavage Studies of γ-aminobutyric acid (GABA) Conjugates
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1  Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal

Abstract: Polycyclic aromatic labels such as naphthalene and pyrene were coupled to the C- terminus of N-benzyloxycarbonyl protected -aminobutyric acid (GABA). The photophysical properties of the corresponding fluorescent conjugates were evaluated, as well as their behaviour towards photocleavage by irradiation in MeOH/HEPES buffer solution (80:20), in a photochemical reactor at different wavelengths (254, 300, 350 and 419 nm), followed by HPLC/UV monitoring.
Keywords: Naphthalene; Pyrene; -Aminobutyric acid (GABA); Photocleavable protecting groups