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Development of new effective methods for the synthesis of lembehynes A–C exhibiting cytotoxic and neuritogenic activity
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Academic Editor: Julio A. Seijas
Published:
14 November 2022
by MDPI
in The 26th International Electronic Conference on Synthetic Organic Chemistry
session Bioorganic, Medicinal and Natural Products Chemistry
Abstract:
The report presents data on our studies on the preparation of the precursor lembehyne A and the complete stereoselective synthesis of natural lembehynes B and C, which have cytotoxic and neuritogenic activity. All methods and approaches to the synthesis of the above-mentioned lembehynes presented in the report are based on the use of the catalytic cross-cyclomagnesiation of 1,2-dienes (Dzhemilev reaction) at the key stage of the synthesis.
Keywords: Lembehynes A-C; 1Z,5Z-dienes; cross-cyclomagnesiation; anticancer and neuritogenic activity
