Development of easy and practical access of  novel imidazo[2,1-b]thiazole derivatives

¹ Laboratoire de Catalyse et Synthèse en Chimie Organique, Faculté des Sciences, Université de Tlemcen, B.P.119, 13000 Tlemcen, Algeria
² Université Belhadj Bouchaib de Ain Témouchent, Faculté des Sciences et de la Téchnologie, B.P. 284, Ain Témouchent 46000, Algeria
³ Université Oran 1, Faculté de Médecine, B.P. 1510 El Menaouar, Oran 31000, Algeria
⁴ Departamento de Química Orgánica, Facultad de Ciencias, Universidad of Santiago De Compostela, Alfonso X el Sabio, 27002 Lugo, Spain

Academic Editor: Julio A. Seijas

Published: 18 November 2022 by MDPI in The 26th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-26-13715 (registering DOI)

Abstract:

The scientific discoveries exposed the privileged skeleton of the imidazo[2,1‐b]thiazole heterocycles for the development of pharmacological compounds. Imidazo[2,1‐b]thiazoles showed interesting potency against a bord range of biological activities such as antibacterial, antifungal, antiviral, anti‐ inflammatory, antihypertensive, anticancer and antioxidant, also used as drug that has significant immunomodulatory properties (Levamisole). Encouraged by these bioactivities, we report herein a new easy and efficient procedure for the preparation of imidazo[2,1-b]thiazole derivatives under green chemistry conditions.

Keywords: Imidazo[2,1‐b]thiazoles; Hetrocycles; Synthesis; Green Chemistry

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