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Depolymerization of heparin benzyl ester in a flow system
Published: 18 November 2022 by MDPI in The 26th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
The preparation of enoxaparin via the base promoted depolymerization is well known. In this paper we present our efforts to convert this preparation into a flow method, Streams of base and ester solutions are combined and heated in a flow reactor, Variations in flow rate, temperature and residence time were examined.
NMR analysis demonstrates that careful control of the reaction parameters affords enoxaparin-like material. Analysis was carried out by NMR spectroscopy and optimum conditions determined.
Keywords: Heparin; enoxaparin; flow reaction
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