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Depolymerization of heparin benzyl ester in a flow system
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1  Department of Chemistry and Biochemistry, Miami University, Oxford, OH USA
Academic Editor: Julio A. Seijas


The preparation of enoxaparin via the base promoted depolymerization is well known. In this paper we present our efforts to convert this preparation into a flow method, Streams of base and ester solutions are combined and heated in a flow reactor, Variations in flow rate, temperature and residence time were examined.

NMR analysis demonstrates that careful control of the reaction parameters affords enoxaparin-like material. Analysis was carried out by NMR spectroscopy and optimum conditions determined.

Keywords: Heparin; enoxaparin; flow reaction